The United States Government As Represented by the Department of Veterans Affairs

Oregon Health & Science University

Other

University of Oklahoma

David Lewinsohn

Deborah Lewinsohn

William H Hildebrand

Curtis McMurtrey

Melanie Harriff

Aaron Nilsen

Haihong Jin

Erin Adams

Cara Froyd

Compositions that include one isolated, class I HLA-E trimolecular complex that includes a peptide ligand unique to-infected cells are disclosed. Isolated compositions that include the three components of the trimolecular complex and/or a polynucleotide encoding one or more of the three components are also disclosed.

Compositions comprising soluble HLA/M. tuberculosis-specific ligand complexes and methods of production and use thereof

Disclosed are small molecules and pharmaceutical compositions comprising them that can be used in treating diseases associated with the major histocompatibility complex (MHC) molecule MR1.

Small molecules that bind MR1

Methods for producing an immune response to(Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional embodiments, methods are disclosed for inhibiting an infection with Mtb, preventing an infection with Mtb, or treating an infection with Mtb. Pharmaceutical compositions for the inhibition, prevention and/or treatment of tuberculosis are also disclosed.

Methods for producing an immune response to tuberculosis

Methods for detecting an infection with Mtb in a subject are disclosed. The methods include detecting the presence of CD8T cells that specifically recognize an Mtb polypeptide. The methods include in vitro assays for detecting the presence of CD8T cells in a biological sample, and in vivo assays that detect a delayed type hypersensitivity reaction. The methods also include detecting Mtb polypeptides and polynucleotides.

Methods for detecting a mycobacterium tuberculosis infection

Methods for detecting an infection with(Mtb) in a subject are disclosed. The methods include detecting the presence of CD8+ T cells that specifically recognize an Mtb polypeptide. The methods include in vitro assays for detecting the presence of CD8+ T cells in a biological sample, and in vivo assays that detect a delayed type hypersensitivity reaction. The methods can also include detecting Mtb polypeptides and polynucleotides. Reagents for the detection of an Mtb infection are also disclosed.

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Methods for detecting an infection with(Mtb) in a subject are disclosed, wherein the subject is a child, a subject with a latentinfection. Method are also disclose for detecting an extra-pulmonaryinfection in a subject. The methods include detecting the presence of CD8T cells that specifically recognize an Mtb polypeptide. The methods include in vitro assays for detecting the presence of CD8T cells in a biological sample.

Methods for producing an immune response to(Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional embodiments, methods are disclosed for preventing an infection with Mtb, or treating an infection with Mtb. Pharmaceutical compositions for the prevention and/or treatment of tuberculosis are also disclosed.

Methods for detecting an infection with(Mtb) in a subject are disclosed. The methods include detecting the presence of CD8+T cells that specifically recognize an Mtb polypeptide. The methods include in vitro assays for detecting the presence of CD8+T cells in a biological sample, and in vivo assays that detect a delayed type hypersensitivity reaction. The methods can also include detecting Mtb polypeptides and polynucleotides. Reagents for the detection of an Mtb infection are also disclosed.

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Portland, OR, United States of America

David Lewinsohn