Teva Pharmaceutical Industries Limited

Makhteshim Chemical Works Ltd.

Plus Chemicals, B.v.

Adama Makhteshim, Ltd.

David Leonov

Judith Aronhime

Ben-Zion Dolitzky

Vinod Kumar Kansal

Ferenc Korodi

Szabolcs Salyi

Anchel Schwartz

Suhail Ahmad

David Ovadia

Raya Sturkovich

Kanhaiya Lal

Melczer Istvan

Szabo Csaba

Marko Kordova

The present invention provides a process for reacting between a phenol derivative and an aromatic substrate under phenolate forming conditions comprising the following steps: (a) reacting a phenol derivative with a base in a polar organic solvent to obtain a phenolate salt, wherein water is removed form the reaction mixture during the reaction, (b) adding the aromatic substrate to the reaction mixture obtained in step (a), (c) heating the reaction mixture of step (b) to a temperature in the range of 80&#xb0; to 1300&#xb0; C., preferably, 90&#xb0; to 1000&#xb0; C. for 2 to 7 hours to obtain a phenoxy substituted aromatic substrate, (d) removing the solvent from the mixture of step (c) and optionally further isolating an purifying the phenoxy substituted aromatic substrate. Optionally, the removal of water during step (a) is in conjunction with partial removal of the organic solvent.

Process for the preparation of substituted cyanophenoxy-pyrimidinyloxy-phenyl acrylate derivatives

Provided is a novel synthesis of quetiapine, and pharmaceutically acceptable salts thereof, in which an alkali metal halide or siliyl halide is included in the reaction mixture.

Process for preparing quetiapine fumarate

The present invention relates to a process to prepare semi synthetic statins, to intermediates formed during said process and to highly purified simvastatin produced by the process.

Highly purified simvastatin compositions

The present invention is directed to the novel forms of torsemide, designated Form V, amorphous torsemide, Dupont Form 2 solvent adduct, Dupont Form 2 ethanol adduct and Dupont Form 2 isopropanol adduct. Methods for their preparation are also disclosed. The present invention also relates to processes for making torsemide modification I. Pharmaceutical compositions containing the new forms of torsemide and methods of using them are also disclosed.

Torsemide polymorphs

Growing community of inventors

Rehovot, Israel

David Leonov