Merck Patent Gmbh

Somalogic, Incorporated

David Lehmann

Anne Baumstummler

Nebojsa Janjic

Urs Ochsner

Luc Felden

Marisa Hohnadel

Sebastien Jouette

Marie Pressel

Frederic Marc-Kreucher

Sandra Laborde

Gael Waiche

Frédéric Marc-Kreucher

Sample preparation unit, preferably for sterility testing: a housing body including at least two ports adapted to serve as fluid inlet and/or fluid outlet, a membrane support, and a lid part such that a membrane chamber is defined adjacent said membrane support. One of at least two ports is arranged so as to allow a fluid transfer to/from a first volume of the membrane chamber at a position upstream of a membrane to be placed on the membrane support, and the other ports arranged to allow fluid transfer to/from a second volume of said membrane chamber at a position downstream of a membrane to be placed on said membrane support. A movable part is provided on housing body such that the movable part and housing body are movable relative to each other, selectively interrupting/establishing fluid transfer between at least one of two ports and the membrane chamber.

Sample preparation unit and sample preparation device

The present invention relates to a method of detecting a microorganism, in particular, in a sample, comprising the steps of a) incubating the sample with a slow off-rate modified aptamer (SOMAmer) comprising a fluorescent label, b) optionally washing the sample, c) analyzing the sample by a fluorescence-based detection method. The invention further relates to a slow off-rate modified aptamer comprising a fluorescent label, wherein the SOMAmer comprises a nucleotide sequence specific for, its use for detectingcells in a sample, and to a microarray or biosensor and a kit comprising at least one of such SOMAmers comprising a fluorescent label.

Method of detecting a microorganism in a sample by a fluorescence based detection method

An apparatus for performing sonication on liquid samples comprises a rack for holding an array of sample vials, an ultrasonic probe with an arrangement of recesses corresponding to the array of sample vials and adapted to respectively receive and contact an outer surface of a bottom portion of a respective one of the sample vials, and a counter-holder with an arrangement of pushing members corresponding to the array of sample vials and adapted to respectively apply a force to a respective one of the sample vials so as to push the bottom portion of each vial into contact with the associated recess of the probe. The apparatus can be used in a method of preparing a sample for detection of cell components (e.g. cell analyte, proteins, nucleid acids etc.) and applying sonication within certain parameter ranges which can provide a universal lysis method that can be applied to a large variety of cells or organisms like all bacteria, viruses, spores, yeast and mold within the same apparatus and process.

Apparatus for performing sonication

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Andolsheim, France

David Lehmann