Boston Biomedical, Inc.

Sumitomo Dainippon Pharma Oncology, Inc.

1globe Biomedical Co., Ltd.

David Leggett

Chiang Jia Li

Wei Li

Youzhi Li

Zhiwei Jiang

Naoaki Shimada

Wataru Hirose

Toshihiko Sone

Matthew Hitron

David Kerstein

The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods of using such compounds to treat disorders in a mammal related to aberrent Stat3 pathway activity; to pharmaceutical compositions containing such compounds.

Stat3 pathway inhibitors and cancer stem cell inhibitors

The present invention provides a compound of the following Formula (1) or a pharmaceutically acceptable salt thereof: wherein X is an oxygen atom and the like; Y is &#x2014;CO&#x2014;, &#x2014;SO&#x2014; and the like; Ris an optionally-substituted Calkyl group, an optionally-substituted Calkylcarbonyl group and the like; Ris an optionally-substituted Calkyl group, an optionally-substituted Calkoxy group, an optionally-substituted amino group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic saturated heterocyclic group and the like; R, R, R, and Rare independently a hydrogen atom and the like which exhibits excellent effects in suppressing the proliferation and sphere-forming ability of cancer cells, and can be useful as an antitumor drug or cell growth inhibitor.

3-substituted carbonyl-naphtho[2,3-B]furane derivative or pharmaceutically acceptable salt thereof

The invention provides naphthofuran compounds, polymorphs of naphthofuran compounds, naphthofuran compounds in particle form, purified compositions that contain one or more naphthofuran compounds, purified compositions that contain one or more naphthofuran compounds in particle form, and methods of using these naphthofuran compounds, polymorphs, purified compositions and/or particle forms to treat subjects in need thereof.

2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer

The invention provides naphthofuran compounds, polymorphs of naphthofuran compounds, naphthofuran compounds in particle form, purified compositions that contain one or more naphthofuran compounds, purified compositions that contain one or more naphthofuran compounds in particle form, methods of producing these naphthofuran compounds, polymorphs, purified compositions and/or particle forms, and methods of using these naphthofuran compounds, polymorphs, purified compositions and/or particle forms to treat subjects in need thereof.

Methods for targeting cancer stem cells

Compounds and compositions for targeting cancer stem cells

The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods of using such compounds to treat disorders in a mammal related to aberrant Stat3 pathway activity; to pharmaceutical compositions containing such compounds.

Growing community of inventors

Milton, MA, United States of America

David Leggett