University of California

Leland Stanford Junior University

David Lee Van Vranken

Barry M Trost

Chengtian Shen

Richard C Bunt

Stanley Chungsing Hiew

Ilandari Dewage Udara Anulal Premachandra

Kevin Andre Scott

Shelley Ren-An Lane

Haoping Liu

Fuqiang Wang

Aaron David Mood

Small molecules comprised of spiroindolinone analogues are provided. Some spiroindolinones are provided with a particular relative stereochemistry in which the indolone carbonyl and all three hydrogens are on the same face of the central pyrrolidine ring. A stereoselective method of synthesis is provided for making some of the spiroindolinones described above. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, fungal infections. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.

Spiroindolinones and therapeutic uses thereof

Ligands useful for transition metal catalyzed bond forming reactions are provided with a metal binding portion having at least one metal binding moiety ##STR1## wherein Ar and Ar' each is an aryl or a heteroaryl. These ligands may be prepared by providing an aromatic carboxylic acid having a diarylphosphino or diheteroarylphosphino substituent on the aromatic ring, and forming an ester or an amide derivative of the carboxylic acid by coupling with a chiral diol or a chiral diamine. The ligands facilitate, for example, flexible strategies for enantiocontrolled construction of five membered carbocyclic rings with varying substitution patterns and high enantioselectivity.

Asymmetric ligands useful for transition metal catalyzed bond forming

Growing community of inventors

Irvine, CA, United States of America

David Lee Van Vranken