William Marsh Rice University

The University of Texas System

Baylor College of Medicine

David Leach

Jeffrey Dale Hartgerink

Simon Young

Andrew Sikora

Jared M Newton

Tania Lopez-silva

Provided herein are peptide-based hydrogels, or neutral multidomain peptide hydrogel (NMDP), as well as uses thereof. The uses include encapsulating cells to induce quiescence for long-term storage and administering to a subject to induce collagen deposition and macrophage infiltration. The disclosed hydrogel is useful for the preservation of stem cells, including maintaining their quiescence and differentiation potential.

Neutral multidomain peptide hydrogels and uses thereof

Provided herein are compositions comprising multi domain peptide (MDP) hydrogels where the peptides that constitute the hydrogel have at least one N6-(1-iminoethyl)-lysine side chain. Also provided are hydrogels that further comprise a STING agonist, an immune checkpoint inhibitor, and/or an anti-cancer therapy. Also provided are methods of using such compositions in the treatment of cancer.

Synthetic multidomain peptide biomaterials that inhibit inducible nitric oxide synthase

In one aspect, the present disclosure provides for novel compositions of matter comprising multi domain peptide (MDP) hydrogels and cyclic dinucleotides (CDNs). Also disclosed are method of using such compositions in the treatment of cancer, including in particular the treatment of head and neck cancers, such as those resistant to CDN therapy.

Hydrogel delivery of sting immunotherapy for treatment cancer

Growing community of inventors

Houston, TX, United States of America

David Leach