Teva Pharmaceutical Industries Limited

Astra Lakemedel Aktiebolag

David Ladkani

Haim Yellin

Ben Z Weiner

Joseph Kaspi

David Avnir

Michael Hayden

Amir Tchelet

Liat Hayardeny

Clara Schoenberger

Colin James Douglas Ross

Mordecai Popovtzer

Shmuel Edelstein

Iris Grossman

John A Kanis

Gad Salemnick

Jacob Vaya

Benjamin Shalita

Zeev Mazor

Stephan Cherkez

Yafit Stark

The present invention provides a method for treating a human subject afflicted with multiple sclerosis or a single clinical attack consistent with multiple sclerosis with a pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier, comprising the steps of:

Genetic markers predictive of response to glatiramer acetate

A method and composition for an improved treatment of human renal osteodystrophy, comprising the administration of 6-40 mcg/d (micrograms per day) of 24,25(OH).sub.2 D.sub.3 in combination with amounts of 1-alpha(OH)D.sub. 3 or 1,25(OH).sub.2 D.sub.3 or DHT.sub.2, which will maintain in the serum of patients the calcium concentration at 10-11 mg/dl (milligrams per deciliter) and the phosphate concentration at 5.5-6.0 mg/dl (milligrams per deciliter) and the numerical multiplication product of calcium x phosphate not more than 60-65.

Combination of cholecalciferol derivatives for the treatment of renal

Process for the preparation of 1'-ethoxy carbonyloxy ethyl esters of penicillins, wherein a compound of the formula ##STR1## in which A is phenyl, phenoxy or 4-hydroxyphenyl, B is hydrogen, an amino group or a protected amino group and Z is hydrogen or a cation selected from the group of alkali metal, tri (lower alkyl ) ammonium and tetra (lower alkyl) ammonium, is reacted with 1-bromoethyl ethyl carbonate in an organic solvent and when B is a protected amino group the protecting group is split off to yield a primary amino group. There are also provided novel compounds of the formula ##STR2## in which Ph is phenyl and R is CH.sub.3 -- or C.sub.2 H.sub.5 --.

Preparation of 1'-ethoxycarbonyl-oxyethyl esters of penicillins

Novel esters of the general formula ##STR1## in which ##STR2## is the acyl residue of a non-steroidal anti-inflammatory compound containing a carboxylic acid function. The novel esters are prepared by reacting an acide R--COOH when R is as above, with 1-haloethyl ethyl carbonate. There are also provided pharmaceutical compositions containing any of the said novel esters.

Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory

1'-Ethoxycarbonyloxyethyl ester of di-n-propylacetic acid, also known as valproic acid. The novel compound is prepared by reacting valproic acid with 1-haloethyl ethyl carbonate. There are also provided pharmaceutical compositions for oral administration containing the said ester.

1'-ethoxycarbonyloxyethyl ester of valproic acid, its preparation and

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Jerusalem, Israel

David Ladkani