University of California

The United States of America As Represented by the United States

David L White

Barry L Engelstad

John P Huberty

Kenneth N Raymond

Kurt A Muetterties

Robert C Scarrow

Beverly A White

The present invention relates to the preparation of amino-acyl-type and catecholamine-type compounds having multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate complexes are formed using these compounds for use as intravenous contrast agents to produce enhanced contrast magnetic resonance images of the heart, liver, biliary tree or upper small intestine. The mono- and di-amino acids, their esters and amides, and catecholamine-like derivatives, of EDTA, DTPA, and the like are prepared. The paramagnetic metal (II) or (III) ion complexes are formed and produce T1-related contrast effects in MR images. The compounds and complexes also appear to have low toxicities and to be relatively rapidly and completely cleared from the tissue of a living mammal, e.g. a human being.

Amino-acyl-type and catecholamine-type contrast agents for MRI

A method is provided utilizing contrast agents which provide increased diagnostic information in the magnetic resonance image of the hepatobiliary system and alimentary tract, especially the small intestine. Novel contrast agents which are N-carboxylated desferrioxamine B complexes with metal ions are provided.

Contrast agents for magnetic resonance imaging of the small intestine

Methods are provided for in vivo magnetic resonance imaging and/or scintigraphic imaging of a subject using chelated transition metal and lanthanide metal complexes. Novel ligands for these complexes are provided.

Imaging agents for in vivo magnetic resonance and scintigraphic imaging

New radiopharmaceutical compositions for use in nuclear medicine comprise radioastatinated benzylguanidine and radioastatinated carboxamidino phenylpiperazine. These compositions are used for treatment of disease, including neuroendocrine tumors, and specifically neuroblastoma.

Therapy agents, methods of preparation, and methods of use

Chelating agents having 1-hydroxy-2-pyridinone (HOPO) and related moieties incorporated within their structures, including polydentate HOPO-substituted polyamines such as spermidine and spermine, and HOPO-substituted desferrioxamine. The chelating agents are useful in selectively removing certain cations from solution, and are particularly useful as ferric ion and actinide chelators. Novel syntheses of the chelating agents are provided.

Growing community of inventors

Oakland, CA, United States of America

David L White