The University of Texas System

Children's Medical Center Corporation

David L Garbers

David Clapham

Timothy A Quill

Dejian Ren

Deijan Ren

Daniel M Hardy

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.

Sperm-specific cation channel, Catsper2, and uses therefor

Sperm-specific cation channel, CATSPER2, and uses therefor

Sperm-specific cation channel, CatSper2, and uses therefor

Disclosed are compositions which bind to mammalian egg zona pellucida in species-specific fashion. Also disclosed are methods for speciating mammalian eggs, identifying species-specific sperm, and providing contraception in a mammalian population. Specifically disclosed are nucleic acid sequences and the corresponding amino acid sequences of specific sperm membrane proteins they encode, whose identification and characterization have permitted development of species-specific contraceptive and fertility compositions and methods.

Species specific egg-binding proteins of sperm

Growing community of inventors

Denton, TX, United States of America

David L Garbers