Corvas International, Inc.

Fostech, Inc.

Other

Baxter International Inc.

Baxter Healthcare Sa

Dendreon Corporation

David L Foster

Matthew Moyle

George Phillip Vlasuk

David Eugene Pereira

Douglas L Looker

Kenneth E Burhop

Michael P Doyle

Geoffrey F Lee

Izydor Z Apostol

Jane P Richards

Stephen P Trimble

Douglas D Lemon

Christopher B Glascock

James C Hartman

Michael R Schick

Eric A Brucker

Ton-That Hai

Edwin G Moore

Provided are multi-mode firearms, triggers, kits, and methods of use that allow a user to select between a semi-automatic firing mode and a pull-and-release firing mode that fires the firearm upon both pulling the trigger and releasing the trigger, by using the selector switch or other mechanism to change the amount the trigger can move. A safe mode that prevents the firearm from firing may also be selected in various example embodiments by using the selector switch or other mechanism to change the amount the trigger can move. In certain example embodiments the trigger cannot move at all in safe mode, can move more in semi-automatic mode, and can move yet more in pull-and-release mode. The modes can be positioned for selection in any order. Kits comprising a trigger assembly and a selector assembly are provided for retrofitting conventional semi-automatic firearms.

Multi-mode firearms, triggers, kits, and methods of use

Provided is an apparatus, system, and method for improved control of trigger systems for semiautomatic firearms, which may include a timed locking mechanism incorporated in the trigger system that locks the trigger in the rearward or pulled position after the trigger is pulled and the action of the firearm is cycling or otherwise out-of-battery. Such a mechanism ensures that the necessary steps occur in the proper sequence in the trigger mechanism, preventing unexpected fires, misfires, and jams. Such trigger locking mechanisms have applicability to dual-mode trigger systems as well as semiautomatic firearms generally, and tend to prevent the ability to bump-fire the firearm. Such trigger locking mechanisms may also provide a tactile signal through the user's trigger finger indicating that the firearm is empty by locking the trigger in the rearward position after the firearm fires its last round and the carrier moves and remains in a rearward position.

Trigger-locking apparatus, system, and method for semiautomatic firearms

Provided in various example embodiments is a firing mechanism for firearms including a trigger with a movable sear attached to the trigger. When dimensional interference occurs within the trigger group, the movable sear is displaced from a seated position to an unseated position, instead of moving the trigger out of the non-firing position. This allows a firearm to be cocked when the trigger is locked in safe mode, and allows a firearm to be placed into safe mode at any time, regardless of the position of the hammer. This functionality improves the effectiveness of automatic trigger locking mechanisms discussed in related applications, and may be applied in various forms to firearms generally.

Trigger having a movable sear and firearms incorporating same

Provided in various example embodiments is an apparatus, system, and method for improved control of selectable dual mode trigger systems for semiautomatic firearms, which may include a timed locking mechanism incorporated in the trigger system that ensures that the carrier is seated before the hammer is actuated, and that the anti-hammer-follow disconnect does not engage out of sequence. Such a mechanism ensures that the necessary steps occur in the proper sequence in the trigger mechanism, so that at any given time the trigger and firearm are ready for the next desired function to occur. The addition of a timed trigger lock mechanism to the trigger as disclosed herein ensures that the sequence of events in the trigger is maintained in the proper relationship, preventing misfires and jams. Such trigger locking mechanisms have applicability beyond dual-mode trigger systems, and may be applied in various forms to semiautomatic firearms generally.

The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.

Reduced side-effect hemoglobin compositions

Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions and recombinant Neutrophil Inhibitory Factors are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.

Neutrophil inhibitors

Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.

Neutropohil inhibitors

Modified hookworm neutrophil inhibitors

Method of detecting neutophil inhibitory factor mimics

Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Such compositions may comprise a glycoprotein isolated from nematodes, particularly of the genus Ancylostoma. These compositions are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.

Growing community of inventors

Lafayette, CO, United States of America

David L Foster