Schering Corporation

David L Cutler

Melton B Affrime

Paul William Glue

Viyyoor Moopil Girijavallabhan

Ashit K Ganguly

Ronald J Doll

Walter Robert Bishop

Ming Liu

Paul Kirschimeier

Loretta L Nielsen

Joseph J Catino

A method comprising administering a PEG -IFN alpha conjugate to an individual afflicted with a viral infection susceptible of treatment with interferon alpha, preferably chronic hepatitis C, is disclosed.

Polyethylene glycol modified interferon therapy

A method is provided for treating conditions that are susceptible of treatment with a cytokine wherein the undesirable side effects normally associated with cytokine administration are diminished or eliminated. The method comprises continuously administering a low dose of a cytokine to an individual afflicted with a condition susceptible of treatment with the cytokine. In a preferred embodiment of the invention, chronic hepatitis C is treated by administering a low dose amount of interferon.

Continuous low-dose cytokine infusion therapy

Methods are provided for treating proliferative diseases, especially cancers, comprising administering (1) a farnesyl protein transferase inhibitor in conjunction with (2) an antineoplastic agent and/or radiation therapy.

Methods for treating proliferative diseases

A method comprising administering a PEG,-IFN alpha conjugate to an individual afflicted with a viral infection susceptible of treatment with interferon alpha, preferably chronic hepatitis C, is disclosed.

Method for treating proliferative diseases

A method for lowering the blood cholesterol levels in mammals and humans by administering IL-10 is disclosed. Preferred dosages and methods of administration are also disclosed.

Method for lowering cholesterol levels with interleukin-10

A method comprising administering a PEG.sub.12000 -IFN alpha conjugate to an individual afflicted with a viral infection susceptible of treatment with interferon alpha, preferably chronic hepatitis C, is disclosed.

Growing community of inventors

Morristown, NJ, United States of America

David L Cutler