Ariad Pharmaceuticals, Inc.

Ariad Gene Therapeutics, Inc.

Araid Gene Therapeutics, Inc.

David L Berstein

Yihan Wang

Leonard W Rozamus

Chester A Metcalf, Iii

Dong Zou

R Mathew Thomas

Chester A Metcalf, Lll

Chester A Metcalf

Chester A Iii Metcalf

This disclosure concerns a new family of phosphorus-containing compounds of Formula (I): and pharmaceutically acceptable derivatives thereof. Compositions containing such compounds and uses thereof are also provided.

Phosphorus-containing compounds and uses thereof

This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is &#x2014;O&#x2014;, &#x2014;S&#x2014; or &#x2014;NR&#x2014;; Q is absent or (if A is &#x2014;O&#x2014;, &#x2014;S&#x2014; or &#x2014;NR&#x2014;) Q may be &#x2014;V&#x2014;, &#x2014;OV&#x2014;, &#x2014;SV&#x2014;, or &#x2014;NRV&#x2014;, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NRVA; K is O or S;each occurrence of Y is independently &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;NR&#x2014;, or a bond linking a Rmoiety to P;each occurrence of Rand Ris independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; andeach occurrence of Ris independently &#x2014;PK(YR)(YR), &#x2014;SO(YR) or &#x2014;C(O)(YR); so long as any R, or Rmoiety linked directly to P is not H;wherein two R, Rand/or Rmoieties may be chemically linked to one another to form a ring;each occurrence of G is independently &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;NR&#x2014; or (M);each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M' moiety may be saturated or unsaturated;each occurrence of x is independently an integer from 1-6; and the other variables are as defined herein.

This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is &#x2014;O&#x2014;, &#x2014;S&#x2014; or &#x2014;NR&#x2014;; Q is absent or (if A is &#x2014;O&#x2014;, &#x2014;S&#x2014; or &#x2014;NR&#x2014;) Q may be &#x2014;V&#x2014;, &#x2014;OV&#x2014;, &#x2014;SV&#x2014;, or &#x2014;NRV&#x2014;, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NRVA; K is O or S;each occurrence of Y is independently &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;NR&#x2014;, or a bond linking a Rmoiety to P;each occurrence of Rand Ris independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; andeach occurrence of Ris independently &#x2014;PK(YR)(YR), &#x2014;SO(YR) or &#x2014;C(O)(YR); so long as any R, or Rmoiety linked directly to P is not H;wherein two R, Rand/or Rmoieties may be chemically linked to one another to form a ring; each occurrence of G is independently &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;NR&#x2014; or (M);each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M' moiety may be saturated or unsaturated;each occurrence of x is independently an integer from-; and the other variables are as defined herein.

Implantable device comprising phosphorus-containing macrolides

This invention concerns a new family of phosphorus-containing macrocycles containing various phosphonate- and phosphonate-containing moieties.

Phosphorus-containing macrocycles

This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA&#x2014; in which: 

This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: 

Growing community of inventors

Waban, MA, United States of America

David L Berstein