Clarapath, Inc.

David Kleinfeld

Charles Cantor

Partha Pratim Mitra

Baris Yagci

Cong Zhang

Steven Smith

The present disclosure relates to systems and methods for facing a tissue block. In some embodiments, a method is provided for facing a tissue block that includes imaging a tissue block to generate imaging data of the tissue block, the tissue block comprising a tissue sample embedded in an embedding material, estimating, based on the imaging data, a depth profile of the tissue block, wherein the depth profile comprises a thickness of the embedding material to be removed to expose the tissue sample to a pre-determined criteria, and removing the thickness of the embedding material to expose the tissue to the pre-determined criteria.

Facing and quality control in microtomy

A histology system includes a microtome configured to produce a tissue section from a tissue block, where the tissue section includes a tissue sample, a transfer system including a transfer medium to transfer the tissue section to a slide, and a vision system. The vision system includes an illumination system configured to illuminate the tissue section on the transfer medium and an imaging system configured to create imaging data of the tissue section on the transfer medium illuminated by the illumination system. The histology system further includes a processor to receive the imaging data and perform one or more quality control analysis based on the imaging data, where the one or more analysis includes a comparative analysis of the tissue section on the transfer medium with at least one of the tissue section on the tissue block or the tissue section on the slide.

The present disclosure also relates to systems and methods for quality control in histology systems. In some embodiments, a method is provided that includes receiving a tissue block comprising a tissue sample embedded in an embedding material, imaging the tissue block to create a first imaging data of the tissue sample in a tissue section on the tissue block, removing the tissue section from the tissue block, the tissue section comprising a part of the tissue sample, imaging the tissue section to create a second imaging data of the tissue sample in the tissue section, and comparing the first imaging data to the second imaging data to confirm correspondence in the tissue sample in the first imaging data and the second imaging data based on one or more quality control parameters.

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New York, NY, United States of America

David Kleinfeld