Dublin City University

Stokes Bio Limited

David Kinahan

Mark Davies

Tara Dalton

Kieran Curran

Conor McCarthy

Brian T Chawke

Damian Michael Curtin

David McGuire

Brian Barrett

Noel Sirr

Ryan J Talbot

Mauro Aguanno

Jens Ducree

Michael Sayers

Robert Burger

Mark Korenke

Damien King

Xiaona Hou

David Mcguire

Sinead Kearney

Nikolay Dimov

Jennifer Gaughran

Louise Barrett

Elizaveta Vereshchagina

The present invention relates to fluidic devices, especially microfluidic devices, for aliquoting and pairwise combinatorial mixing of a first set of liquids with a second set of liquids. The device architecture is designed to move liquids in two separate phases, a first phase where the liquids are exposed to a first directional force field to move the liquids in a first direction, from a reservoir to aliquot chambers, and a second phase where the liquids are exposed to a second directional force field to move the liquids in a second direction, from the aliquot chambers to the mixing chambers. The first and second directional force fields that the device is exposed to may be achieved using a single directional force field (i.e. a rotor driven centrifugal force field) and by re-orienting the position of the device with respect to the centrifugal forces between the first and second phases of operation. The device architecture comprises reservoirs for each of the first fluids and reservoirs for each of the second fluids. Each reservoir is fluidically connected to aliquoting chambers, either arranged in parallel or in series, for providing aliquots of the fluid which may be metered. The conduits providing fluid communication between the reservoirs and aliquoting chambers are arranged in a first direction. A series of mixing chambers is also provided, and each mixing chamber is fluidically connected to one aliquot chamber for a first liquid and one aliquoting chamber for a second liquid. The conduits providing fluid communication between the aliquoting chambers and mixing chambers are arranged in a second direction.

Fluidic device for aliquoting and combinatorial mixing of liquids

Provided herein is a biological detection system and method of use wherein the biological detection system comprises at least one mixer or liquid bridge for combining at least two liquid droplets and an error correction system for detecting whether or not proper mixing or combining of the two component droplets have occurred.

Biological detection system and method of use

Growing community of inventors

Kildare, Ireland

David Kinahan