Pacific Biosciences of California, Inc.

Naked Biome, Inc.

Amersham Plc

Symbiome, Inc.

David Kagen Hanzel

Paul S Peluso

Thang Pham

David R Rank

John Lyle

Fred C Christians

Geoff Otto

Insil Park

Sonya Clark

Arekadiusz Bibillo

Emma Taylor

Stephen Wilson Turner

Jonas Korlach

Geoffrey Alan Otto

Paul Mitsis

Arek Bibillo

Mark E Shannon

Yizhong Gu

Yonggang Ji

David Russell Rank

Wensheng Chen

Sharron Gaynor Penn

Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.

Polymerases for nucleotide analogue incorporation

Described herein are compositions and methods of treatment for acne and other skin disorders involving the use of probiotics. In certain aspects, microbes included in the probiotics have been engineered or selected for the treatment of specific skin disorders.

Compositions and methods for treatment of skin disorders

Compositions that include polymerases with features for improving entry of nucleotide analogs into active site regions and for coordinating with the nucleotide analogs in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.

Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

Active surface coupled polymerases

Surface comprising DNA polymerase having mutations bound through an affinity tag

Presented are a novel myosin-like protein particularly expressed in human heart and muscle, isolated nucleic acids encoding the myosin-like protein, compounds and compositions derivable directly or indirectly therefrom, and diagnostic and therapeutic methods for using the same.

Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle

Growing community of inventors

Palo Alto, CA, United States of America

David Kagen Hanzel