Nektar Therapeutics

Novartis Ag

David K Gong

Kirsten M Cabot

Jayne E Hastedt

Dennis M Hester

Bing Yang

Cynthia L Stevenson

David D Lesikar

David B Bennett

Hi-Shi Chiang

Russ Lehrman

S Russ Lehrman

The present invention provides storage stable dry powder compositions of IL-4R. The powder compositions demonstrate superior chemical and physical stability over their solution counterparts, particularly upon storage under varying conditions of temperature and humidity. Moreover, the powders, as prepared, possess good aerosol properties, which are maintained upon storage.

Storage stable powder compositions of interleukin-4 receptor

Storage stable power compositions of interleukin-4 receptor

The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 &#x3b1;-helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).

Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation

The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 &agr;-helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).

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Foster City, CA, United States of America

David K Gong