Eli Lilly and Company

David Joseph Garmene

Erik James Hembre, Ii

Kevin Matthew Gardinier

Jianliang Lu

Steven James Green

Yen Dao

Albert Kudzovi Amegadzie

Macklin Brian Arnold

Patrick Gianpietro Spinazze

Helen Jane Szekeres

Michael Brunavs

The present invention relates to a melanin concentrating hormone antagonist compound of formula (1): wherein R, R, R, R, L, R, Rand Rare as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases. 

MCH receptor antagonists

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I): wherein R, R, R, R, L, R, Rand Rare as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases. 

The present invention relates to a melanin concentrating hormone antagonist compound of formula I: wherein '-----' is absent or is optionally a bond; q is 1 or 2; Ris independently selected from hydrogen, &#x2014;C-Calkyl, halo, hydroxy, &#x2014;C-Chaloalkyl, &#x2014;C-Calkoxy, cyano, &#x2014;O&#x2014;C-Ccycloalkyl, and &#x2014;OC-Chaloalkyl; Ris selected from the group consisting of hydrogen, &#x2014;C-Calkyl, hydroxy, &#x2014;C-Calkoxy, cyano, &#x2014;C-Chaloalkyl, &#x2014;OC-Chaloalkyl, and halo; Ris selected from the group consisting of hydrogen, &#x2014;C-Calkyl, &#x2014;C-Chaloalkyl, &#x2014;C-CalkylOH, &#x2014;C-Ccycloalkyl, &#x2014;CHC-Ccycloalkyl, &#x2014;C-Calkyl-O&#x2014;C-Calkyl, &#x2014;C(O)C-Calkyl, &#x2014;C(O)C-Chaloalkyl, &#x2014;CH-thiazole, phenyl, benzyl, tetrahydrothiopyranyl, and tetrahydropyranyl, wherein the cycloalkyl, tetrahydrothiopyranyl, tetrahydropyranyl and thiazolyl group is optionally substituted with one or two groups independently selected from the group consisting of halo, hydroxy, C-Calkyl, and &#x2014;C-Chaloalkyl; or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture thereof, useful in the treating, preventing or ameliorating of symptoms associated with obesity and related diseases. 

5- [4-(azetidin-3-yloxy)-phenyl]-2-phenyl-5H-thiazolo[5,4-C] pyridin-4-one derivatives and their use as MCH receptor antagonists

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Indianapolis, IN, United States of America

David Joseph Garmene