Cornell Research Foundation Inc.

David Jon Christini

Jay M Edelberg

Bruce B Lerman

Kenneth M Stein

Peter Nicholas Jordan

A real-time detection technique and a real-time, adaptive, model-independent control technique for detecting and stabilizing pathological physiological rhythms, such as repolarization alternans, on the basis of the rate dependence of excitable tissue such as cardiac and neuronal tissue is presented. Unlike other control methods, which require a number of beats to locate the period-1 fixed point, the technique locates the period-1 fixed point almost instantaneously, rapidly eliminating any higher-period or aperiodic rhythms.

Adaptive diastolic interval control of action potential duration alternans

Nonlinear-dynamical control, also known as chaos control, can modulate human cardiac electrophysiological dynamics by stabilizing an unstable target rhythm. Intracardiac, repolarization alternans detection methods are disclosed that operates on the basis of amplitude or repolarization duration detection. Also disclosed are control methods for stabilizing repolarization alternans.

Intracardiac detection and control of repolarization alternans

The present invention provides implantable physiological or pathophysiological biosensors. The subject biosensors comprise tissue or cells capable of carrying out a physiological or pathophysiological function, which can be used to monitor a chemical, physiological or pathophysiological variable associated with the physiological or pathophysiological function. In one embodiment, the tissue or cells are coupled via an electrical interface to an electronic measuring device or an electronic amplifying device. In another embodiment, the tissue or cells are coupled via an electrical interface to endogenous tissue or cells, including the blood. Preferably, the tissue or cells are excitable tissue or cells such as cardiac tissue or cells and neuronal tissue or cells. The subject biosensors may be placed, inserted or implanted in any animal including but not limited to a mouse, rat, rabbit, pig, cat, dog, cattle, horse, sheep or human. The present invention also provides various methods which employ a biosensor of the present invention. Such methods include a method of monitoring physiological or pathophysiological function, a method of regulating output of a signal to a subject, and a method for controlling heart function.

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Brooklyn, NY, United States of America

David Jon Christini