Medtronic Vascular, Inc.

David Johnson

Stephen Nash

Grace Kelly

Patricia O'Beirne

Stephen Gormley

A method of manufacturing a drug delivery device includes forming a undercoat on an outer surface of a dipping mandrel, forming a tack coat on an outer surface of the undercoat, depositing granular particles on at least a portion of the tack coat, forming an overcoat on the formed tack coat, trapping the granular particles between the tack coat and the overcoat and removing an outermost portion of the overcoat to expose a portion of the granular particles. A system for treating a vascular condition includes a catheter having an inflation lumen, an elastomeric drug delivery device disposed on the catheter and in fluid communication with the inflation lumen, a plurality of expandable pores disposed within an outer layer of the elastomeric drug delivery device and at least one therapeutic agent disposed within at least a portion of the plurality of expandable pores.

Methods for incorporating a drug into an elastomeric medical device

A catheter is disclosed that has a detachable tip for delivery of a therapeutic substance to a chronic total occlusion (CTO) within a body vessel. The tip is made from a biodegradable material and includes an active agent dispersed therethrough. The detachable tip pierces into the calcified lesion, detaches from the catheter, and remains embedded within the lesion as the tip degrades, thereby releasing the active agent. The active agent is a therapeutic substance effective to treat of a CTO. The active agent may be a drug, an enzyme, bacteria, or a parasite that degrades or softens the calcified lesion.

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Turloughmore, Ireland

David Johnson