Smithkline Beecham Corporation

Other

Replidyne, Inc.

David John Holmes

Karen Anne Ingraham

Magdalena Zalacain

Sanjoy Biswas

Richard Lloyd Warren

Alison Francis Chalker

James Raymond Brown

Chi Young So

Christopher Michael Traini

Min Wang

Michael Arthur Lonetto

Deborah Dee Jaworski

Stephanie Van Horn

Martin Karl Russel Burnham

John Peter Throup

Thomas B Mathie

Nicola Gail Wallis

Alison Frances Chalker

Lisa Kathleen Shilling

Jennifer E Ray

John Edward Hodgson

Michael Terence Black

Richard Oakley Nicholas

Leslie Marie Palmer

Robert King Stodola

Christine Marie Debouck

Jeffrey L Mooney

Yi Yi Zhong

Pan Fong Chan

James Yigong Ge

Elizabeth Jane Lawlor

Patrick Vernon Warren

Daniel Robert Gentry

David Justin Knowles

Damien McDevitt

Anna Lisa Kosmatka

Martin K R Burnham

Richard L Warren, Jr

Alexander Philip Bryant

Marie J Mazzulla

Chi Yong So

Karen A Ingraham

Andrea Marra

Martin Karl Burnham

David Justin Charles Knowles

Howard Kallender

Jason Craig Fedon

Stewart Campbell Pearson

David William Holden

John Timothy Lonsdale

Karen M O'Dwyer

Earl William May

Anna Lisa Lenox

Chantal Myriam Petit

Glenn Scott Van Aller

Robert Dwayne Lunsford

Gee W Lau

Sauli J Haataja

Jun Yu

Yigong Ge

Chanal Myriam Petit

A method for image recognition of a material object that utilizes graphical modeling of the corner points of a vertex which includes projecting a point on a digital display to an inward depth, a one half pixel distance in the plane of the display, with a conic to a digital display, and a square block containing one half size child blocks that are scaled to depth, projecting the corner points of a vertex and replacing the bisecting points of edge features detected in a digital display scaled at an increasing rate of congruency to the dimensions of an object. The method may further include producing a digital image of the material object, providing a central processing unit, providing memory associated with a central processing unit; providing a display associated with a central processing unit; loading the digital image into the memory; defining the edges of features within the digital image; and a finding fight crucial points from registrations projected on to an edge feature display.

Method and apparatus for determining offsets of a part from a digital image

The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infections in materials.

metRS2

The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.

Peptidyl t-RNA hydrolase (PTH)

The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.

A method for inserting a cassette into a nucleic acid molecule to produce a modified nucleic acid molecule, e.g., a nucleic acid-cassette fusion, is described. The method involves the use of polymerase chain reaction, thereby permitting precise targeting of the desired site in the molecule, but does not require ligation. Also described is the use of this method for high throughput screening the resulting modified nucleic acid molecules.

Methods for producing modified nucleic acid molecules

The invention provides lacR polypeptides and polynucleotides encoding lacR polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lacR polypeptides to screen for antibacterial compounds.

lacR from Streptococcus pneumoniae

The invention provides fucose kinase promoter polynucleotides and methods for producing and using such polynucleotides, as well as their variants, agonists and antagonists, and their uses.

Fucose kinase

The invention provides Phosphatidylglycerophosphate Synthase polypeptides from (&ldquo;pgsA polypeptides&rdquo;). Also provided are methods for utilizing pgsA polypeptides to screen for antibacterial compounds.

Phosphatidylglycerophosphate synthase from Staphylococcus aureus

The invention provides pgsA polypeptides and polynucleotides encoding pgsA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pgsA polypeptides to screen for antibacterial compounds.

PgsA

The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.

inFB

The invention provides trmA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recominant techniques from strepococcus pneumoniae. Also provided are methods for utilizing polypepides to screen for antibacterial compounds.

trmD

The invention provides FabG polypeptides and polynucleotides encoding FabG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabG polypeptides to screen for antibacterial compounds.

Nucleic acids encoding Streptococcus pneumoniae FabG

The invention provides yhxB polypeptides and polynucleotides encoding yhxB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yhxB polypeptides to screen for antibacterial compounds.

yhxB

The invention provides tktA polypeptides and polynucleotides encoding tktA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tktA polypeptides and polynucleotides to screen for antibacterial compounds and for the detection of

TktA from Streptococcus pneumoniae

The invention provides ytgP polypeptides and polynucleotides encoding ytgP polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ytgP polypeptides to screen for antibacterial compounds.

ytgP

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West Chester, PA, United States of America

David John Holmes