James Black Foundation Limited

David John Dunstone

Sarkis Barret Kalindjian

Iain Mair McDonald

Ildiko Maria Buck

Michael John Pether

Matthew John Tozer

Caroline M Low

Katherine Isobel Steel

Jonathan Michael Davies

Martin Lyn Hudson

Nigel Paul Shankley

Elaine Anne Harper

Paul Wright

James Black

Caroline Minli Rachel Low

Ian Duncan Linney

Robert A Hull

Katherine Isobel Mary Steel

Gillian Fairfull Watt

Sonia Patricia Roberts

Jeremy Gilbert Vinter

Martin Keith Walker

Elliot James Lilley

David Andrew Sykes

Eric Peter Griffin

Laurence Wright

John David Gaffen

Michael J Bodkin

Robert Antony David Hull

Gastrin and cholecystokinin receptor ligands

Histamine H.sub.3 receptor ligands

CCK and gastrin receptor ligands

Compounds of formula (Ia), (Ib), or (Ic), wherein A represents a group having two fused rings, or a group of formula (Id), R.sup.1.sub.(m) represents up to 6 substituents, K represents --O--, --S--, --CH.sub.2 --, --N(R.sup.2)-- or --N(COR.sup.2)--, in which R.sup.2 is H or C.sub.1 to C.sub.3 alkyl, W is a carbonyl, sulfonyl or sulfinyl group, provided that at least one of W and X contains carbonyl, Y and Z are as given in the description, and their pharmaceutically acceptable salts are ligands at CCK and/or gastrin receptors. ##STR1##

Gastrin and cck receptor ligands

Gastin and CCK receptor ligands

Bicyclooctane and bicycloheptane derivatives

The compounds of the formula I ##STR1## and their pharmaceutical acceptable salts, which are defined herein, are ligands for cholecystokinin and/or gastrin receptors.

Bicyclo 2,2,2!octane derivatives

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David John Dunstone