Pharmacia & Upjohn Company

The Upjohn Co.

Other

Pfizer Corporation

Pharmacia Corporation

David John Anderson

Steven Ronald Turner

Gordon L Bundy

Joseph Walter Strohbach

Suvit Thaisrivongs

Karen Rene Romines

Ronald B Gammill

Paul A Aristoff

Richard Charles Thomas

Harvey I Skulnick

Michael D Ennis

Paul D Johnson

Barbara E Loughman

Jackson B Hester, Jr

Stephen T Schlachter

Mark E Schnute

Ruben Alberto Tommasi

Richard Allen Nugent

Toni-Jo Poel

Joel Morris

Louis L Skaletzky

George P Luke

Theresa M Schwartz

Steven Paul Tanis

Douglas K Hutchinson

Malcolm Wilson Moon

Robert C Gadwood

Valerie Ann Vaillancourt

Atli Thorarensen

Robert Louis Hoffman

Paul D May

Scott D Larsen

Lisa Marie Thomasco

Michael J Genin

Fred L Ciske

Thomas M Judge

Paul K Tomich

James A Nieman

David R Graber

Michael John Bohanon

Euibong J Kim

Robert L Hoffman

Chih-Ping Yang

Lee S Banitt

Qingwei Zhang

Allison J Wolf

The invention provides a compound of formula I:wherein G, R, R, and Rhave any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of preventing or treating a herpesvirus infection using such compounds or salts.

Antiviral compounds

Heterocycle carboxamides as antiviral agents

Sultam and sultone derived oxazolidinones

A process for preparing a compound of the formula I:

Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings

The present invention relates to compounds of formula I and II which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl&lsqb;b&rsqb;pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus.

Compounds useful to treat retroviral infections

A compound of Formula (I): ##STR1## or pharmaceutical acceptable salts thereof wherein X is NR.sub.1 ; R.sub.1 is H, C.sub.1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R.sub.1 is --(CH.sub.2).sub.h -aryl, --COR.sub.1-1, --COOR.sub.1-2, --CO--(CH.sub.2).sub.h --COR.sub.1-1, C.sub.1-6 alkyl sulfonyl, --SO.sub.2 --(CH.sub.2).sub.h -aryl, or --(CO).sub.i --Het; R.sub.2 is H, C.sub.1-6 alkyl, --(CH.sub.2).sub.h -aryl, or halo; R.sub.3 and R.sub.4 are independently H or halo; R.sub.5 is H, C.sub.1-12 alkyl optionally substituted with one or more halo, C.sub.3-12 cycloalkyl, C.sub.1-6 alkoxy; m and n taken together are 1 or 2. The compounds are useful antimicrobial agents.

A compound of Formula (I): ##STR1## or pharmaceutical acceptable salts thereof wherein X is S(O).sub.g or O; R.sub.2 is H, methyl, or OH; R.sub.3 and R.sub.4 are independently H or halo; R.sub.5 is H, C.sub.1-12 alkyl, optionally substituted with one or more halo, C.sub.3-12 cycloalkyl, C.sub.1-6 alkoxy; and g is 0, 1, or 2. The compounds are useful antimicrobial agents.

Phenyloxazolidinones having a C--C bond to 4-8 membered heterocyclic

The present invention provides thiadiazolyl and oxadiazolyl phenyl oxzolidinone compounds of formula I ##STR1## wherein Q is thiadiazolyl or oxadiazolyl; wherein X.sup.1 and X.sup.2 are independently hydrogen, fluorine or chlorine; and

Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents

Pyranone compounds useful to treat retroviral infections

4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl�b!pyran-2-ones

Compounds useful in the treatment of inflammation structurally represented as Formula I ##STR1## one of X or Y is H and the other is selected from the group consisting of: ##STR2## or X and Y are taken together to form a ring selected from the group consisting of: ##STR3## as herein defined. The compounds are useful as anti-inflammatory and anti-arthritic agents.

Phosphonoacetic esters and acids as anti-inflammatories

The present invention provides certain novel substituted benzothiazoles, benzimidazoles and benzoxazoles which are useful as inhibitors of leukotriene biosynthesis and/or as inhibitors of the action of lipoxygenase and/or as inhibitors of mucus secretion in mammalian metabolism. They are thus employed wherever it is medically necessary or desirable to inhibit these systems.

Substituted benzothiazoles, benzimidazoles, and benzoxazoles

Novel cyclized .omega.-carboxyethyl mono or dithiocarbanilic acids are disclosed as immunoregulatory agents, useful in the treatment of organ transplant reject phenomenon and autoimmune diseases particularly where a delayed hypersensitivity component has been established, such as multiple sclerosis. Additionally described is the use of certain cyclized .omega.-carboxyalkyl mono- or dithiocarbamic acids and certain cyclized .omega.-carboxyalkyl mono- or dithiocarbamic acids.

Carbamic acid derivatives as selective immunosuppresive agents

Growing community of inventors

Kalamazoo, MI, United States of America

David John Anderson