Wisconsin Alumni Research Foundation

University of Illinois

Other

Onexio Biosystems LLC

Gilson, Inc.

Salus Discovery, LLC

Stacks To the Future LLC

Lynx Biosciences, Inc.

Ration, Inc.

David James Beebe

Scott M Berry

David John Guckenberger

Jay W Warrick

David J Guckenberger, Jr

Duane S Juang

Ben P Casavant

Ivar Meyvantsson

Jeffrey S Moore

Erwin Berthier

Glenn M Walker

Hongrui Jiang

Benjamin J Moga

Hannah M Pezzi

Glennys A Mensing

Peter Cavnar

Lindsay Strotman

Jiaquan Yu

Eric Arthur Johnson

Kent B Chase

Matthew B Wheeler

Richard R Burgess

Michael W Toepke

Terry D Juang

David T Eddington

Abhishek K Agarwal

Jaisree Moorthy

Nicholas Lawrence Abbott

Jo E Handelsman

Liang Dong

Dongshin Kim

Joshua M Lang

Ian K Glasgow

Brian Johnson

Chao Li

Layla J Barkal

Jose Jimenez

Patrick H McMinn

Jason Yu

Joon-Seo Park

Tony Escarcega

Sarah Teren

Michael J MacDonald

Bin Zhao

Gary E Borodic

Justin C Williams

Jake Myre

Mark A Shannon

William Howard Tepp

Sabine Pellett

Garrick D S Smith

Lee G Wilke

Chorom Pak

Michael L Philpott

Kevin Richard Fawcett

Ashleigh Brooks Theberge

Gregory J Robinson

Robin Hui Liu

Mary Regier

Caroline Alexander

David H O'Connor

Erwin Berthler

Joseph M Bauer

Henry Zeringue

Tamara S Rodems

Benjamin P Casavant

Eric Sackmann

Erwin Barthler

Pamidighantam Bharathi

Hyuk-Jeen Suh

Clark Bullard

Amy Paguirigan

Theodorus De Groot

Thomas C Friedrich

Jay Warrick

Theodorus Evan De Groot

Berwin Berthier

Scott M Barry

John Guckenberger

Jay W Warwick

Hongmei Yu

Edmond Wai Keung Young

Francisco J Atencia-Fernandez

Natalie Callander

Stephen M Johnson

Vinay V Abhyankar

Shigeki Miyamoto

Brian E Schwartz

Steven J Pauls

Mark E Burkard

Timothy D Rand

Brant R Kochsiek

A sample extraction cassette and method are provided to test for a target in a sample. The sample is obtained on a swab. The swab is inserted into a chamber in a case and into contact with a contact portion of a membrane. The contact portion of the membrane is axially moved into sequential communication with a wash fluid and a reaction fluid. The reaction fluid reacts with the target to provide a visual display corresponding to the presence of the target.

One-step sample extraction cassette and method for point-of-care molecular testing

A method and device of creating a lumen model in a microwell plate defining a well is provided. A rod is inserted through the well of the microwell plate and the well is filled with a polymerizable material. The material is polymerized in the well. The rod is removed from the well of the microwell plate such that the polymerized material defines a lumen.

Method and device for creating organotypic lumen models in a microwell plate

A platform and method for testing antibiotic sensitivity of a polymicrobial infection is provided. The platform includes a body defining a plurality of sets of chambers and a plurality of wells. Each set of chambers has a plurality of chambers adapted for culturing microbes of the polymicrobial infection therein. Each well is associated with a corresponding set of chambers and has an input in fluidic communication with the outlets of the plurality of chambers in the corresponding set of chambers. Selected antibiotic therapies may be received in the wells which fluidically connect the plurality of chambers in a corresponding set of chambers such that microbes cultured in the plurality of chambers in the corresponding set of chambers are in soluble factor contact.

Platform and method for testing antibiotic sensitivity of a polymicrobial infection

A method and device are provided for detecting a target in a biological sample. The target binds to a solid phase substrate. First and second cavities in a plate are filled with an oil. The first and second cavities are in fluid communication with each other. The solid phase substrate is magnetically drawn sequentially from a drop of the biological sample in the first cavity, through the oil, into a drop of the reaction solution in the second cavity. A change in a parameter of the drop of the reaction solution indicates the presence of the target.

Device and method for accelerated material extraction and detection

Provided herein are devices, systems, and methods for concentration and detection of sample components. In particular, provided herein are lateral flow devices, systems, and methods that utilize flow control of samples.

Sample concentration and detection systems and methods

A method and a device are provided for facilitating the disaggregation of a plurality of solid phase substrate as the plurality of solid phase substrate are transferred from a first location to a second location. A plurality of solid phase substrate are deposited at the first location and a plurality of particles are added to the plurality of solid phase substrate. A force is generated to draw the plurality of solid phase substrate from the first location to a second location. The plurality of particles causes clumps of the plurality of solid phase substrate to break apart as the plurality of solid phase substrate are moved in response to the force.

Device for facilitating the isolation of targets from a biological sample

Systems, methods, compositions of matter, and kits for undermedia repellency are disclosed. In some cases, these involve a first volume of a first liquid presented in a second volume of a second liquid above a first location of a first surface. The first liquid, second liquid, and first location can have properties sufficient to give rise to undermedia perfect liquid repellency.

Systems and methods for undermedia repellency

Provided herein are microtiter plates, systems, and uses thereof. In particular, provided herein are cell culture (e.g., microtiter plates) with a plurality of wells that comprise diffusion channels, systems comprising the devices (e.g., comprising cells), and use of the devices and systems in co-culture applications (e.g. in high throughput screening) and biological assays.

Microtiter plate and uses thereof

A device and method are provided to facilitate the handling of a volume of fluid. The device includes an elongated tube having an open first end and a second end. The tube defines a reservoir for receiving the volume of fluid. A stanchion has a first end received within the reservoir of the tube and a second end projecting from the open end of the elongated tube. In operation, the elongated tube is deposited in a first capsule having fluid therein. The first capsule is centrifuged such that the volume of fluid is received in a reservoir in the tube through the open end. The tube is removed from the first capsule and positioned in a second capsule such that the open end of the tube is spaced from a closed end of the second capsule. The second capsule is centrifuged such that the volume of fluid is expelled from the reservoir of the tube.

Method of facilitating the handling of a volume of fluid

An open microfluidic system is provided. The open microfluidic system including the extreme wettability of exclusive liquid repellency (ELR), open microchannels with high lateral resolution and low profile, various valve arrangements, capable of a broad range flow rates, and capable of spatially and temporally trapping particles in open fluid.

Open microfluidic system and various functional arrangements therefore

A platform and method for conducting multi-variable combinational interactions are provided. An array of multiplexing chambers in formed in a body. The body also includes a common well communicating with each multiplexing chamber of the array of multiplexing chambers and a plurality of variable wells. Each of variable wells communicates with at least one multiplexing chamber of the array of multiplexing chambers. The common well is loaded with a first variable and different variables are loaded in each of the plurality of variable wells. The interaction of the first variable with at least one of the different variables in each multiplexing chamber of the array of multiplexing chambers is observed.

Platform and method for multi-variable screening

A method of sample preparation for streamlined multi-step assays is provided. The method includes the step of providing a microfluidic device including a reservoir defined by a surface configured to repel an aqueous solution. A dried reagent is provided on a portion of the surface and the reservoir is filled with an oil. A first droplet formed from the aqueous solution is positioned on the dried reagent so to pick-up and re-dissolve the dried reagent therein so as to expose the portion of the surface. In addition, a second droplet of an aqueous solution may be deposited on a hydrophilic spot patterned on the surface. A magnetic force may be configured to interact magnetically with the paramagnetic beads within the first droplet to move the droplet through the oil in the reservoir or to move the paramagnetic beads from the first droplet, through the oil, into the second droplet.

Volume-free reagent addition and exclusion-based sample preparation for streamlined multi-step assays

Growing community of inventors

Monona, WI, United States of America

David James Beebe