Agilent Technologies, Inc.

Alcon, Inc.

Caire Diagnostics Inc.

Aperon Biosystems Corp.

Ngk Spark Plug Company, Limited

Avago Technologies General IP Pte, Ltd.

Powervision, Inc.

Aerocrine Ab

Apieron Biosystems Corp.

David James Anvar

David J Chazan

Bhairavi Parikh

Andrew Goodwin

Bryan Patrick Flaherty

Richard Earl Haven

Ryan R Leard

Solomon Ssenyange

Julie Elizabeth Fouquet

Jonathan P Fay

Datong Chen

Ganapati R Mauze

John Stewart Wenstrand

Mark Andrew Troll

James Stone

Shalini Venkatesh

Kevin Nason

Frederick A Stawitcke

Dan-Hui Dorothy Yang

Hiroyuki Nishiyama

Shigeya Aoyama

Heidi Linch Reynolds

Brian Awabdy

Tatsunori Ito

Brian A Awabdy

Masahiro Takakura

John Hammerman

Autumn Talbott

Takahiro Yokoyama

Todd Smith

Vivek Balasubramanyam

An asthma management system and method are disclosed for collecting environmental and individual health data to predict the onset of asthma symptoms to allow for preventative therapy tailored on an individual basis. In one embodiment a computer system is in electrical communication with an individual user interface and one or more environmental factor collection points via a communications network. The user interface is adapted to send and receive asthma-related data including asthma profile and real-time asthma status data to the computer system via the communication network, and the environmental factor collection points are adapted to send and receive data to the computer system via the communications network. The computer system further comprises one or more processors connected to memory, and are programmed with executable instructions for implementing one or more algorithms for (1) collecting and storing in memory data received from the individual user interface and from the environmental factor collection points, (2) aggregating the data received from the individual user interface and the environmental factor collection points, and (3) implementing one or more algorithms to generate an asthma symptom onset prediction based on the aggregated data. The onset prediction is then communicated to the user interface. In addition, the one or more processors are further programed with executable instructions to revise one or more asthma symptom onset prediction algorithms where the generated asthma onset prediction and an individual's real-time asthma status data indicate a prediction error.

Asthma management system and method

Fluids incorporated into intraocular lenses and their methods of use. In some embodiments the fluids are silicone oils, and in some embodiments they are used in accommodating intraocular lenses.

Fluid for accommodating intraocular lenses

A measurement system is disclosed that includes features for detecting the presence of nitric oxide from a gas sample, such as exhaled breath. The measurement system includes an assembly that introduces one or more reducing gases into a reactor-sensor assembly to help stabilize the sensor signal response and improve the performance of the assembly over time. Suitable reducing gases include hydrogen gas (H), carbon dioxide (CO), benzaldehyde, bisphenol A, and other similar compounds. The reducing gas may be introduced directly from one or more surrounding gases or through tubing or inline piping. The reducing gas may be generated from the liquid or solid forms.

Nitric oxide detection device with reducing gas

A high-sensitivity analyzer for nitric oxide in exhaled breath at levels of 200 ppb or less with a sensor containing cytochrome C is rendered capable of multiple uses without the need for installing a new sensor for each use. This capability is achieved by regenerating the analyzer after each use by purging the sensor and surrounding regions with NO-free air in a controlled manner, preferably in pulses separated by equilibration periods.

Analyzer for nitric oxide in exhaled breath with multiple-use sensor

Highly sensitive devices for detecting nitric oxide and/or other gaseous analytes in gaseous samples are improved by the incorporation of a carbon monoxide scavenger in the interior of the device or in the device packaging. The release of carbon monoxide within the housing of the device by the plastic used in the construction of the housing or by anything within the device that releases carbon monoxide causes a loss in sensitivity due to competition between the carbon monoxide and the nitric oxide for the binding sites on the device sensor. The scavenger corrects this by either catalyzing the oxidation of carbon monoxide to the less competitive carbon dioxide or immobilizing the carbon monoxide by affinity-type or covalent binding. Analogous effects are achieved for analytes other than nitric oxide but that likewise encounter interference from carbon monoxide in binding to sensors.

Reduction of carbon monoxide interference in gaseous analyte detectors

A sensor and method for making a sensor includes providing a substrate having an adhesion layer with a first functional group operatively associated with a sol-gel composition having a second functional group, and at least one linker material for connecting the first functional group to the second functional group. In another embodiment, a sensor and method for making the sensor includes providing a sol-gel layer operatively associated with a sol-gel precursor solution that includes at least one co-polymer and at least one solvent adapted to resist the deformation of the sol-gel layer by decreasing evaporation, decreasing cross-linking, increasing intermolecular forces, or increasing elasticity.

Methods and procedures for stabilization and performance optimization of multi-layer sol-gel chemical and biochemical sensors

The present invention is a system and method of conditioning the sample and surrounding environment of an exhaled breath sensor. It includes (i) using a particular molecular sieve for a triple purpose: (a) maintaining the sensor at a constant relative humidity during storage, (b) equilibrating the incoming breath stream to the same relative humidity as the sensor, and (c) eliminating the analyte from the environment around the sensor during storage. The present invention also includes removal of interfering components from the exhaled breath, such as carbon dioxide, as well as a thermal management technique.

Sample conditioning and environmental control techniques for gas sensor

Methods and apparatus for pupil detection are described. First light is emitted from a first light source at a first illumination angle relative to the axis of a detector. Second light is emitted from a second light source at a second illumination angle relative to the axis. The first light and the second light can have substantially equal intensities. The second illumination angle is greater than the first illumination angle. Reflected first light and reflected second light are received at the detector. The difference between the reflected first light and the reflected second light can be determined. The difference can be used to detect the pupils of a subject's eyes.

Apparatus and method for detecting pupils

The degradation over time that is commonly seen with analyte-binding proteins when used as sensors for trace amounts of an analyte in a gaseous mixture is reduced by maintaining the sensor in a low-oxygen or oxygen-free environment.

Trace gas sensor with reduced degradation

Arrays are provided for multiplexed evanescent scanning by allowing for high-contrast Surface Plasmon Resonance images thereof. The arrays target features are typically biopolymeric in nature, though they may be any sort of chemical or ligand. The type of scanning is such that there is no need for probe labeling. As no labeling is required, a broader range of applications than otherwise possible is facilitated. In the subject arrays, target features are set upon a noble metal film deposited on a substrate. Interfeature areas are adapted to trap, divert and/or bleed-away light so that light directed through the substrate will not be reflected by those areas and interfere with evanescent scanning of the reflective areas upon which intended target features are provided. Geometric and materials-based light attenuating features are contemplated. Arrays as described, hardware and software as required for reading such arrays, and associated methodology are covered.

Arrays for multiplexed surface plasmon resonance detection of biological molecules

Bubble stability within an optical switch is enhanced by controlling the expansion or movement of a bubble from a liquid-containing trench into available adjacent spacing. Typically, the adjacent spacing is formed between an optical waveguide substrate and a heater substrate, where the heater substrate includes a microheater for forming the bubble. The bubble enhancement is provided by intentionally altering surface features along at least one of the substrates.

Bubble stability in an optical switch

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Mountain View, CA, United States of America

David James Anvar