The University of Texas System

Pg-Txl Company, L.p.

Other

Massachusetts Institute of Technology

Seecure Taiwan Co., Ltd.

Wallace Technologies

Ceil>point, LLC

Cell>point, LLC

Taiwan Hopaz Chems, Mfg. Co., Ltd.

Taiwan Hopax Chems. Mfg. Co., Ltd.

David J Yang

Dong-Fang Yu

Sidney Wallace

Chun Li

E Edmund Kim

Chun W Liu

Ali Azhdarinia

Chang-Sok Oh

Saady Kohanim

Dongfang Yu

Andrew S Thompson

Abdallah Cherif

Changsok Oh

Li-Ren Kuang

Michael Wallace

Tsung-Tien Kuo

Firas Mourtada

Jerry L Bryant, Jr

Wayne Steven Yang

I-Chien Wei

David Rollo

Richard O Mendez

Chi-Shiang Ke

Min-Ching Chung

Wei-Chung Chang

E Delpassand

Jerry Bryant

Zuxing Kan

S Quadri

A Cherif

E Edmond Kim

F David Rollo

Akira Tanaka

Tomio Inoue

Katsumi Tomiyoshi

Tommy L Lee

Mithu Chanda

Chun-Wei Liu

Chang Sok Oh

A composition for cross talk between estrogen receptors and cannabinoid receptors including a chelator and a receptor ligand is provided. A method of synthesizing the composition is also provided, and the composition may be further prepared in pharmaceutical formulations or kits for therapy or molecular imaging.

Composition for cross talk between estrogen receptors and cannabinoid receptors

Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

The invention include glycopeptides having a glycoside and a peptide covalently bound through an amide bond. The glycopeptides may also include a diagnostic or therapeutic agent bound to the glycopeptide. A metal, such as a radionuclide, may also be chelated to the glycopeptide. Specific embodiments of the invention relate to glycopeptides made of chitosan covalently bound to a poly(amino acid) such as poly(glutamic acid) or poly(aspartic acid). Diagnostic agents conjugated to the glycopeptide may facilitate imaging. Specific therapeutic agents that may be conjugated to the glycopeptide include anticancer drugs, rheumatoid arthritis drugs, anticoagulants, anti-angiogenesis drugs, apoptosis drugs, osteoporosis drugs, steroids, and anti-inflammatory drugs. Some agents, such as radionuclides, may have both diagnostic and therapeutic effects. The glycopeptides may be made by combining a glycoside and a peptide in the presence of a carbodiimide and an acid group activator to form an amide bond between the glycoside and the peptide.

Glycopeptide compositions

Novel methods of synthesis of ethylenedicysteine-sugar conjugates and therapeutic and diagnostic applications of such conjugates are disclosed. Methods of synthesizing these conjugates in high purity are also presented as using starting materials such as thiazolidine carboxylic acid. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these conjugates prepared herein, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

Efficient synthesis of ethylenedicysteine-sugar conjugates for imaging and therapy

The invention provides, in a general sense, a new labeling strategy employing compounds that are NSchelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor angiogenesis targeting ligand, a tumor apoptosis targeting ligand, a disease receptor targeting ligand, amifostine, angiostatin, monoclonal antibody C225, monoclonal antibody CD31, monoclonal antibody CD40, capecitabine, a COX-2 inhibitor, deoxycytidine, fullerene, herceptin, human serum albumin, lactose, leuteinizing hormone, pyridoxal, quinazoline, thalidomide, transferrin, or trimethyl lysine. The present invention also pertains to kits employing the compounds of interest, and methods of assessing the pharmacology of an agent of interest using the present compounds.

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The present invention relates generally to the fields of chemistry and radionuclide imaging. More particularly, it concerns compositions, kits and methods for imaging and therapy involving Ncompounds and derivatives.

Compositions and methods for cellular imaging and therapy

Compositions and methods for imaging and for chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns agents comprising a targeting moeity comprising a beta-adrenergic receptor targeting compound conjugated or embedded with ethylenediamine. The present invention also concerns methods of application of such agents for imaging and treatment of cardiovascular diseases, and kits for preparing a radiolabeled therapeutic or diagnostic agent.

Image-guided therapy of myocardial disease: composition, manufacturing and applications

The invention provides, in a general sense, a new labeling strategy employingTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated toTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.

Bisaminoethanethiol-targeting ligand conjugates and compositions

Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X&#x2014;Y&#x2014;X, wherein Y comprises two or more carbohydrate residues covalently attached to one another, Xand Xare diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, Xand Xare diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.

Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications

A swing arm assembly becomes a balancing mechanism for a foldable telescope golf cart. The swing arm assembly adjusts the inclined angle of the golf beg on the golf cart, and thus adjusts the location of the center of gravity of the cart. The golf cart is maintained in a balanced state when the center of gravity falls upon the centerline of the cart wheels. The golf cart and swing arm assembly can be converted from compact size to full size, or vice versa, by a single action.

Foldable telescope golf cart having a balancing mechanism

Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging

Metal ion-labeled bis-aminoethanethiol-targeting ligand conjugates, compositions, and methods for tissue-specific disease imaging

Compositions for imaging pancreatic beta cells comprise chelator-antidiabetic agent conjugates and optionally chelated metals.

Mechanism-based targeted pancreatic beta cell imaging and therapy

The present invention provides automated systems for the purification of radioisotopes, the formulation of radiopharmaceuticals or both. In preferred embodiments the radioisotopes are produced by a generator. In further preferred embodiments the automated systems comprise replaceable cassettes for easy replacement of the system's networks of tubing. Also provided are replaceable cassettes and kits for use with the automated systems of the invention. The invention further provides methods of using an automated system to purify radioisotopes, formulate radiopharmaceuticals or to do both in series.

Automated system for formulating radiopharmaceuticals

Growing community of inventors

Sugar Land, TX, United States of America

David J Yang