Glycomed, Inc.

David J Tyrrell

Kevin R Holme

Patrick N Shaklee

Robert J Stack

Peter Fugedi

Weisheng Liang

Masayuki Ishihara

Robert J Tressler

Methods of making and using, as prophylactics or therapeutics for preventing or treating certain diseases including cancer, O-desulfated heparin compositions, preferably 2-O, 3-O desulfated heparin compositions, wherein the methods permit regulating the degree of 2-O, 3-O desulfation to produce compositions that are variably desulfated upto about 99% and 75% desulfated at the 2-O and 3-O positions, respectively.

Method for controlling O-desulfation of heparin

A novel class of highly sulfated maltooligosaccharide having heparin-like activity is described, as well as methods for using these oligosaccharides to treat certain diseases including cancer, and retinopathies.

Sulfated maltooligosaccharides with heparin-like properties

Methods of making and using, as prophylatics or therapeutics for preventing or treating certain diseases including cancer, O-desulfated heparin compositions, preferably 2-O, 3-O desulfated heparin compositions, wherein the methods permit regulating the degree of 2-O, 3-O desulfation to produce compositions that are variably desulfated including about 99% and 75% desulfated at the 2-O and 3-O positions, respectively.

Method for controlling o-desulfation of heparin and compositions

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Alameda, CA, United States of America

David J Tyrrell