Kaiser Optical Systems Inc.

David J Strachan

Joseph B Slater

James M Tedesco

Harry Owen

A compact Raman/fluorescence probe is capable of collecting spectra from a relatively large spot size as compared to traditional confocal Raman probes. The inventive probe collects spectra from an area or 1 mm or greater, preferably 3&#x2013;12 mm or more, compared to current instruments which utilize spot sizes on the order of 2&#x2013;60 microns. The larger spot size facilitates the collection of statistically useful data from inhomogeneous and laser-sensitive samples, among other applications. Potential pharmaceutical applications include tablet dosage level measurements, as well as online and at-line quality-control (QC) monitoring opportunities. Other applications include tablet identification as a forensic tool to identify counterfeit pharmaceutical products; granulation and blend uniformity for improved formulation via better process understanding, and reactor cleanliness validation.

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Timonium, MD, United States of America

David J Strachan