Janssen Biotech, Inc.

Centocor, Inc.

Applied Molecular Evolution

Centocor Ortho Biotech Inc.

Other

Centocor Research & Development, Inc.

Ortho Biotech Holding LLC

David J Shealy

David M Knight

Jill M Giles-Komar

Bernard Scallon

David Peritt

George A Heavner

Alain Philippe Vasserot

Raymond W Sweet

Sheng-Jiun Wu

David Matthew Marquis

Jing Yang

Vedrana Stojanovic-Susulic

Yan Chen

Eric Michael Smith

Bailin Liang

Debra Gardner

Michael W Lark

Susan H Tam

Jinquan Luo

Xiao-Yu R Song

Xiao-yu R Song

Marian Kruszynski

Sam Wu

Audrey Baker

Yan Chan

Susan Tam

Bernhard Scallon

Anti-IL-6 antibodies and antirheumatics are useful to treat and suppress IL-6 related conditions, such as rheumatoid arthritis.

Anti-IL-6 antibody

Methods of suppressing rheumatoid arthritis using an anti-IL-6 antibody

Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as systemic lupus erythematosus.

Method for treating lupus by administering an anti-IL-12 antibody

Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriasis.

An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Method of treating lupus by administering an anti-IL-12 antibody

The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.

Anti-TNF antibodies, compositions, methods and uses

Anti-IL-12 antibodies and compositions

A pen-injector device comprising an anti-IL-6 antibody with a liquid formulation have applications in diagnostic and/or therapeutic compositions, methods and devices.

Pen-injector device containing anti-IL-6 antibodies

Nucleic acids encoding anti-IL-12 antibody

Method of treating Crohn's disease by administering an anti-IL-12 antibody

Method for treating psoriasis by administering an anti-IL-12 antibody

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Anti-IL-6 antibodies, compositions, methods and uses

The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS: 1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.

An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriatic arthritis.

Method for treating psoriatic arthritis by administering an anti-IL-12 antibody

Growing community of inventors

Downingtown, PA, United States of America

David J Shealy