Leland Stanford Junior University

Other

The United States Government As Represented by the Department of Veterans Affairs

David J Schurman

Dennis R Carter

Robert Lane Smith

R Lane Smith

Robert L Piziali

Gary S Beaupr&eacute;

Jay A Mandell

A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within to joint space of diarthrotic joints. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene expression of growth factors that are inhibitory to type II collagen expression.

Method for in vivo, ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling

A method for in vivo, ex vivo and in vitro regeneration of cartilage, collagen and bone remodeling by intermittently applied hydrostatic pressure consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The intermittent hydrostatic pressure is applied at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene expression of growth factors that are inhibitory to type II collagen expression.

Method for in vivo, ex vivo and in vitro repair and regeneration of cartilage

A system for determining image intensity of a radiograph includes an illuminator for providing lighting to the radiograph, an image reference standard having a predetermined color, a digital imaging device for obtaining a digital image of the radiograph and the image reference standard, a computer for receiving and storing the digital image and for executing programs, and an image analysis program being executed on the computer for providing a first image intensity value of a target area in the radiograph and a second image intensity value of the image reference standard and for computing a normalized image intensity value of the target area using the first and second image intensity values. In one embodiment, the image reference standard is an image reference standard of a black color or a white color.

Method and apparatus for quantitative and comparative analysis of image intensities in radiographs

A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene, expression of growth factors that are inhibitory to type II collagen expression.

Method for in vivo ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling

Novel prostheses, particularly femoral prostheses, are provided. The subject devices are characterized by the presence of a curvilinear collar. Also provided are methods of implanting a prosthesis in a manner sufficient to provide for a pressure profile at the collar interface in which the pressure increases from the endosteal to the periosteal surface of the bone.

Prostheses having curvilinear collars

An articulated knee prosthesis in which a femoral implant has a condyle section and a femoral stem that is cemented into the femur. A tibial implant carries a tibial plateau section on which is mounted a stop plate for engaging the condyle section and arresting movement of the knee beyond its fully extended position. The tibial implant includes a tibial stem that is cemented into the tibia. A pivotal connection between the two implants is positioned posteriorly of the implant and at an elevation above a lowermost point of the condyle section (when the implants are fully extended). The pivot axis of the connection and the stems are positioned with respect to each other so that upon the implantation of the implant, the patient's tibia is moved in an anterior direction as compared to the normal anatomical position of the tibia relative to the femur. At least a portion of the hinged connection, which frequently includes the pivot axis, is located posteriorly of portions of the femur proximate the knee joint to maximize the arc through which the knee can be flexed.

Growing community of inventors

Stanford, CA, United States of America

David J Schurman