Other

Bristol-myers Squibb Pharma Company

David J Nelson

Jingwu Duan

Carl P Decicco

Chu-Biao Xue

Milind Rajopadhye

John A Barrett

Alan P Carpenter Jr

Thus the present invention describes novel compounds comprising 1-10 targeting moieties; a chelator (Ch); and 0-1 linking groups (Ln) between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the chelator is capable of conjugating to a cytotoxic radioisotope. The present invention also provides novel compositions of the compounds of the invention, kits and their uses in treatment of diseases associated with MMPs.

Matrix metalloproteinase inhibitors

Amide derivatives as inhibitors of matrix metalloproteinases, TNF-&agr;, and aggrecanase

An item of wearing apparel is disclosed comprising a sash tie and sash tie holder which is conveniently mounted in place under the collar of a shirt without the necessity of tieing a conventional necktie knot. The sash tie fits over the holder and is provided with fastening means, such as conventional commercially available reusable cooperating tape of the hook and loop type. Corresponding tape is provided on the shirt of the wearer and holds the necktie securely in place.

Sash tie and holder

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Newark, DE, United States of America

David J Nelson