Focal, Inc.

Other

The University of Texas System

The Coca-cola Company

Genzyme Corporation

David J Nedder

Dean M Pichon

George E Selecman

David A Melanson

Jeffrey Alan Hubbell

Amarpreet S Sawhney

Luis Z Avila

Arthur J Coury

Shikha P Barman

Stephen D Goodrich

Ronald S Rudowsky

Mark T Kieras

Bradley C Poff

Donald L Elbert

John C Spiridigliozzi

Chandrashekar P Pathak

Thomas S Bromander

Marc A Levine

Thomas Bromander

Douglas Ely

Joseph M Ladina

Douglas J Weaver

J Jeffrey Kablik

Marc Alan Levine

Douglas J K Weaver

John R Sousa

John D Knight

Thomas P Hambleton

Daniela Homza-Stark

Albert H Linder

Douglas JK Weaver

A gas powered spraying device that can be used for single or multi-part reactive medical polymer compositions is provided. A fluid or one or more reactive solutions are sprayed independently at a tissue surface, and the spraying of each solution of multi-component embodiments is controlled by a separate valve. Each solution is provided with a separate spray outlet, and each spray outlet is surrounded by an annular sheath of flowing gas. Gas flow is provided at two or more flow levels, including a high level flow for active spraying and a low level bypass flow to remove drips and prevent clogging, which can improve device reliability. Gas pressure can be used to drive fluid to its spray outlet, as well as to spray the fluid from the outlet to the tissue surface.

Self-cleaning fluid delivery device for medical applications

A closure for a bottle. The closure includes an outer cap. An audio device and a triggering mechanism are positioned within the outer cap. A water block is positioned on the outer cap so as to prevent water from penetrating into the audio device.

Audio closure

An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as &ldquo;priming&rdquo;. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, &ldquo;priming&rdquo; can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.

Redox and photoinitiator systems for priming for improved adherence of gels to substrates

Redox and photoinitiator systems for priming and improved adherence of

An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as 'priming'. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, 'priming' can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gellable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.

Device for priming for improved adherence of gels to substrates

Growing community of inventors

Attleboro, MA, United States of America

David J Nedder