Harvard College

University of Michigan

Dana-farber-cancer Institute Inc.

Seoul National University

Beth Israel Deaconess Medical Center, Inc.

Forsyth Dental Infirmary for Children

Charité – Universitätsmedizin Berlin

Other

Massachusetts Institute of Technology

National Institutes of Health, a Component of the US Dept. of Health & Human Services

The General Hospital Corporation

University of Massachusetts

Children's Medical Center Corporation

Tufts College

Dearing, Matthew T.

David J Mooney

Omar Abdel-Rahman Ali

Eduardo Alexandre Barros E Silva

Glenn Dranoff

Sidi A Bencherif

Elliot Earl Hill, Jr

Roger Warren Sands

Alexander G Stafford

Hyun Joon Kong

Tanyarut Boontheekul

William Leo Murphy

Weiwei Aileen Li

Jaeyun Kim

Sandeep T Koshy

Xuanhe Zhao

Nathaniel D Huebsch

Martin C Peters

Rajiv Desai

Praveen Arany

Lonnie D Shea

Kyu Hwan Oh

Zhigang Suo

Toshihisa Kawai

Joost Johan Vlassak

Aristidis Veves

Jon A Rowley

Jeong-Yun Sun

Widusha R K Illeperuma

Jianyu Li

Lan Cao

David H Kohn

Kamal H Bouhadir

Angelo S Mao

Robert Samuel Langer

Donald Elliot Ingber

Joseph P Vacanti

Michael Super

Conor James Walsh

Edward J Doherty

Mark J Cartwright

Neel Satish Joshi

Georg N Duda

Herman H Vandenburgh

Ellen T Roche

Stefanie Utech

Thomas Michael Braschler

Luo Gu

Max Carlton Darnell

Simon Young

Benjamin Seiler

Or Gadish

Cathal J Kearney

Anthony Atala

David A Weitz

David A Edwards

David T Scadden

Michael Aizenberg

Jeffrey F Bonadio

Thomas E Schaus

Robert G Dennis

Jeff Lichtman

Bruce J Baum

Craig Reed Halberstadt

Petra Eiselt

Esther Amstad

Ovijit Chaudhuri

Leatrese Harris

Kuen Yong Lee

Des White

Ting-Yu Shih

Amanda Graveline

Kathleen Martinick

Uyanga Tsedev

Gabriel Cooper Spalding

Kenneth M Yamada

Lawrence J Bonassar

Raluca Ostafe

Omar Ali

Jonathan Garlick

Christopher M Madl

Steven Obiajulu

Frank A Pigula

Kangwon Lee

Stephen Michael Kennedy

William W Yuen

Cristina Borselli

Dimitry Shvartsman

Maria M Xu

Hannah Storrie

Christine A Cezar

Eduardo Alexandra Barros E Silva

Elliott Earl Hill, Jr

Genevieve M Kruger

Alexander Sing Cheung

Jae-Won Shin

Edna Cukierman

Wai Kung Wong

Matthew T Dearing

The invention provides polymer compositions for cell and drug delivery.

Injectable cryogel vaccine devices and methods of use thereof

The provided herein are methods and compositions for eliciting an immune response to an antigen, such as cancer and microbial antigens.

Biomaterials for modulating immune responses

Disclosed herein are compositions and methods for labeling cells using click chemistry reagents. The compositions and methods disclosed herein provide a specific and efficient means of localizing desired agents to a variety of cell types in vivo and in vitro.

Compositions and methods for labeling and modulation of cells in vitro and in vivo

The present disclosure provides click-crosslinked hydrogels and methods of use.

Click-crosslinked hydrogels and methods of use

The present invention is directed to a biocompatible adhesive system comprising a) a hydrogel comprising a first polymer network and a second polymer network, wherein the first polymer network comprises covalent crosslinks and the second polymer network comprises ionic crosslinks; b) a high density primary amine polymer; and c) a coupling agent. The present invention also provides methods preparing and using the biocompatible adhesive system.

Biocompatible adhesives and methods of use thereof

The present invention comprises compositions, methods, and devices for enhancing an endogenous immune response against a cancer. Devices and methods provide therapeutic immunity to subjects against cancer.

Combination vaccine devices and methods of killing cancer cells

Provided are fast relaxing hydrogels that are useful for regulating cell behavior and enhancing tissue regeneration, e.g., bone regeneration.

Viscoelastic hydrogels with fast stress relaxation

The invention provides methods and compositions for reducing tumor-mediated immune evasion and inducing patient-specific immunization.

Peritumoral and intratumoral materials for cancer therapy

The present invention is directed to reduced and highly oxidized polysaccharides, such as alginates, that are useful for encapsulating therapeutic or diagnostic agents, or lipid based nanoparticles, e.g., liposomes or virosomes, encapsulating therapeutic or diagnostic agents, prior to their delivery into a subject, as well as methods for making and using them.

Reduced and oxidized polysaccharides and methods of use thereof

Disclosed are compositions and related methods of recapitulating bone marrow stroma using scaffold materials (e.g., a porous alginate hydrogel scaffold) containing one or more cellular differentiation factors, and one or more growth factors. Such methods and compositions promote the formation of an ectopic nodule or site that can improve transplanted cell engraftment and selectively drive the development of lymphocytes and the reconstitution of the adaptive immunity after hematopoietic stem cell transplant.

Recapitulating the hematopoietic niche to reconstitute immunity

The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.

Pathogen vaccines and methods of producing and using the same

Embodiments herein described provide antigen-presenting cell-mimetic scaffolds (APC-MS) and use of such scaffolds to manipulating T-cells. More specifically, the scaffolds are useful for promoting growth, division, differentiation, expansion, proliferation, activity, viability, exhaustion, anergy, quiescence, apoptosis, or death of T-cells in various settings, e.g., in vitro, ex vivo, or in vivo. Embodiments described herein further relate to pharmaceutical compositions, kits, and packages containing such scaffolds. Additional embodiments relate to methods for making the scaffolds, compositions, and kits/packages. Also described herein are methods for using the scaffolds, compositions, and/or kits in the diagnosis or therapy of diseases such as cancers, immunodeficiency disorders, and/or autoimmune disorders.

Antigen-presenting cell-mimetic scaffolds and methods for making and using the same

A composition comprising mesoporous silica rods comprising an immune cell recruitment compound and an immune cell activation compound, and optionally comprising an antigen such as a tumor lysate. The composition is used to elicit an immune response to a vaccine antigen.

Mesoporous silica compositions comprising inflammatory cytokines comprising inflammatory cytokines for modulating immune responses

The present invention provides injectable compositions comprising cells encapsulated in hydrogel capsules and methods of preparing these compositions. The present invention also provides methods for using these compositions to promote hematopoiesis and to treat or prevent cardiovascular and immunological disorders in a subject.

Hydrogel compositions comprising encapsulated cells and methods of use thereof

The present invention provides methods and compositions for promoting dental tissue repair and/or regeneration, methods for promoting differentiation of dental pulp stem cells, methods for treating periodontal diseases, and methods for treating infection of a dental pulp in a subject in need thereof by contacting the tissue with a composition comprising a triacrylate capable of promoting dental pulp stem cells adhesion and/or proliferation.

Methods and compositions for dental tissue repair and/or regeneration

Growing community of inventors

Sudbury, MA, United States of America

David J Mooney