Johns Hopkins University

The Wistar Institute

Other

University of Liverpool

David J Meyers

Philip A Cole

Ronen Marmorstein

Erin M Bowers

Chandrani Mukherjee

Xin Liu

Ling Wang

Steven Paul Rannard

Andrew Owen

Caren Laura Freel Meyers

James Hobson

Charles Williams Flexner

Paul Curley

Marco Siccardi

Amer Al-Khouja

The present invention provides a composition comprising nanoparticles of prodrugs of certain pharmaceutically active agents, wherein the nanoparticles of prodrugs are dispersed within a carrier material. The present invention further provides processes for the making of the same.

Prodrug compositions

A screening bucket system for screening debris out of otherwise clean materials. The screening bucket system generally includes a bucket adapted to be connected to a loader. The bucket includes a rear wall, a pair of side walls, and a blade across its front end. A floor of the bucket is hingedly connected at a front end to the side walls by a hinge. The rear end of the floor includes a rod mount to which a lift rod powered by a motor is rotatably connected such that, when the lift rod is raised or lowered, the free end of the floor raises and lowers while the hinged end of the floor rotates about the hinge. A screen may be positioned on the floor such that materials on the screen may be sifted of debris by activating the lift rod to rapidly raise and lower the floor and screen.

Screening bucket system

The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain.

Methods and compositions for modulating P300/CBP activity

Growing community of inventors

Towson, MD, United States of America

David J Meyers