May & Baker, Ltd.

David J Lythgoe

Garry Fenton

Michael J Ashton

Keith A Stuttle

David Riddell

Christopher G Newton

Donald I Dron

Christopher Smith

Andrew W Bridge

Robert K Chambers

Neil Victor Harris

Barbara Joyce Broughton

Ian Michael McFarlane

Edward Lunt

Libert C Saunders

Peter J Warne

David W Gilmour

Adnan H Al-Shaar

Diane M Kelsey

Ian McClenaghan

Peter Lowden

Duncan C McDougall

Malcolm P Toft

Therapeutically useful isoquinolinone derivatives of the formula A--X--R.sup.3, wherein A represents a group of the formula: ##STR1## wherein R.sup.1 and R.sup.2 represents cycloalkyl, alkyl, alkenyl or alkynyl optionally substituted by halogen or cycloalkyl, or represents optionally substituted aryl or heteroaryl, R.sup.4 represents hydrogen, halogen, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or heteroaryl, or a group R.sup.6 O-- wherein R.sup.6 represents alkyl, aryl or arylalkyl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula:

Isoquinolinones

Therapeutically useful pyrrolo[2,1-a]phthalazine derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 represent cycloalkyl, optionally substituted alkyl, alkenyl, alkynyl, aryl or heteroaryl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula:

Pyrrolophthalazines

Pyrrolo[2,1-a]isoquinoline derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each represent cycloalkyl or alkyl, alkenyl or alkynyl which may be halogen-substituted, or optionally substituted aryl or heteroaryl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula:

Pyrroloisoquinolines useful as hypercholesterolemic and

Ethene derivatives

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David J Lythgoe