Amgen Inc.

Other

David J Lloyd

Zhulun Wang

Xiaoshan Min

Murielle M Veniant-Ellison

Darren L Bates

Donghui Shi

Ian Nevin Foltz

Neeraj Jagdish Agrawal

Junming Yie

Christopher Murawsky

Jinghong Wang

Glenn N Sivits, Jr

Renee Komorowski

Brandon C P Clavette

Shu-yin Ho

Kenneth William Walker

Mark Leo Michaels

Pavel V Bondarenko

Jerry Ryan Holder

Irwin Chen

Shu-Chen Lu

Shanaka Stanislaus

Todd Hager

Aiko Umeda

Method of treating metabolic diseases and disorders using a composition comprising a GLP-V/GIPR antigen binding protein fusion protein are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the composition comprises the C-terminus of a GLP-1 analog fused to the N-terminus of the light chain variable or heavy chain variable region of an antibody or functional fragment thereof that binds GIPR, optionally with a linker in between.

Method of treating or ameliorating metabolic disorders using antagonistic binding proteins for gastric inhibitory peptide receptor (GIPR)/GLP-1 receptor agonist fusion proteins

Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.

Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (GIPR) in combination with GLP-1 agonists

Nucleic acid molecules encoding binding proteins for gastric inhibitory peptide receptor (GIPR)

A fuel-air mixture regulator for multiple cylinder four-cycle internal combustion engines is positioned between the carburetor and the intake manifold whereby the fuel and air mixture flowing from the carburetor passes through the fuel-air mixture regulator and undergoes an increase in velocity and turbulence enroute to the cylinders for better combustion. The mixture regulator includes a housing having a plurality ports. A thin, resilient, flexible reed for each port is adapted to seat thereover when the engine is not operating and moves away from the port to variably open same for flow of fuel-air mixture therethrough in response to pressure differentials on the reeds during engine operation. The size of the port opening is reduced at lower engine speeds and assures optimum fuel-air mixing and high velocity air flow even at such lower speed.

Fuel-air mixture regulator for internal combustion engines

Growing community of inventors

Thousand Oaks, CA, United States of America

David J Lloyd