Louisiana State University and Agricultural & Mechanical College

National Institutes of Health, a Component of the US Dept. of Health & Human Services

The Uab Research Foundation

Wake Forest University

Loma Linda University

Washington State University

The University of Alabama

David J Lefer

Rakesh P Patel

Mark Thomas Gladwin

Daniel B Kim-Shapiro

Edward H Oldfield

Alan N Schechter

Richard O Cannon, Iii

Christian J Hunter

Gordon G Power

Ryszard Marek Pluta

Christopher Kevil

Ming Xian

Jianming Kang

David J Polhemus

Richard O Cannon

Ryszard Pluta

This invention is directed to compositions and methods for treating a condition of the heart. In an embodiment, the invention is directed to a method of treating a subject in need thereof, wherein the method comprises ablating at least one nerve of the renal artery of the subject; and administering to the subject a therapeutically effective amount of cells.

Compositions and methods for treating cardiac injury

Methods of treating a subject who has chronic tissue ischemia are disclosed. The methods can include administering to the subject a pharmaceutical composition comprising inorganic nitrite or a pharmaceutically acceptable salt thereof, for a time and in an amount sufficient to result in blood vessel growth in the ischemic tissue. The subject can be diagnosed as having a medical condition that results in persistent or recurring restriction of blood supply to a tissue, for example, peripheral artery disease, diabetes, atherosclerotic cardiovascular disease or defective wound healing. The methods can include the step of identifying a suitable subject.

Use of nitrite salts in chronic ischemia

The embodiments herein generally relates to compounds and methods for releasing HS in a pH dependent manner. In particular, the invention provides compounds of various formulations which release HS in a controlled, predictable and sustained manner upon contact with an aqueous environment, such as the circulatory system of an animal, and which are thus suitable for in vivo delivery of HS.

Compounds for pH-controlled release of hydrogen sulfide

It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

Use of nitrite salts for the treatment of cardiovascular conditions

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Saint Bernard, LA, United States of America

David J Lefer