Amoco Corporation

Gene-trak Systems

David J Lane

Jyotsna S Shah

Susan M Barns

Ayoub Rashtchian

Donald N Halbert

Kyriaki Parodos

Amelia Buharin

Samuel W Chan

Mark L Collins

William G Weisburg

Raymond M Nietupski

Theodore B Pitman

James E Awell

Ray A McMillian

Jeffrey F Lemontt

Walter King

Jing Liu

Jonathan M Lawrie

Jane Warshaw

Patrick Groody

Susan Raposa

Hsien-Yeh Hsu

Raymond M Nietuspki

Erko Stackebrandt

David Sobell

David A Hendricks

Stephen G Wilson

Janice M McCarty

Susan Rigby

George Parsons

The invention features nucleic acid probes and methods for detecting Pneumocystis carinii (e.g., human or ferret P. carinii) in hybridization assays.

Nucleic acid probes and methods for detecting Pneumocystis carinii

Nucleic acid fragments capable of hybridizing to rRNA of a Salmonella species and not capable of hybridizing to rRNA of Escherichia coli.

Detection of salmonella

The invention relates to methods of using nucleic acid probes capable of specifically hybridizing to rRNA of Campylobacter jejuni, C. coli and C. laridis and not to rRNA or rRNA genes of Pseudomonas aeuroginosa, E. coli or Salmonella typhimunium for the detection of Campylobacter in clinical, food and other samples.

Detection of campylobacter

Nucleic acid probes capable of specifically hybridizing to rRNA of Yersinia enterocolitica and not to rRNA of non-Yersinia enterocolitica are described along with methods utilizing such probes for the detection of Yersinia enterocolitica in food and other samples.

Nucleic acid probes for the detection of yersinia enterolitica

The nucleic acid compositions and methods are presented which are capable of preferentially hybridizing to rRNA or rDNA of Vibrio bacteria over rRNA or rDNA of non-Vibrio bacteria having utility assay means for detection.

Compositions and methods for the detection of bacteria in the genus

Nucleic acid probes capable of hybridizing to rRNA of Staphylococcus aureus and not to rRNA of non-Staphylococcus aureus are described along with methods utilizing such probes for the detection of Staphylococcus aureus in food and other samples.

Nucleic acid probes for the detection of staphylococcus aureus

A method for detecting and/or quantitating specific DNA and/or RNA transcripts of human papillomavirus (HPV) is described. Nucleic acid probes specific for DNA or transcripts are used to determine the amount of the DNA or transcripts, and to ascertain the degree of amplification of certain high-oncogenic HPV genes. The method provides an accurate and reliable method for prognosticating serious cervical neoplasias and cancers.

Detection of HPV transcripts

The present invention relates to a method of selectively detecting Giardia lamblia in a sample. The method makes use of at least one nucleic acid probe which is a DNA or PNA sequence which hybridizes, under appropriate conditions, to the ribosomal RNA or the ribosomal DNA of Giardia lamblia but does not hybridize to the ribosomal RNA or the ribosomal DNA of other organisms (non-Giardia lamblia organisms) which may be present in a sample.

Nucleic acid probes for the detection of Giardia lamblia

Nucleic acid probes capable of hybridizing to rRNA or rDNA of Pneumocystis carinii and not to rRNA or rDNA of non-Pneumocystis are described along with methods utilizing such probes for the detection of Pneumocystis carinii in clinical samples.

Nucleic acid probes for the detection of Pneumocystis carinii

Oligonucleotide probes for detection of salmonella

Nucleic acid probes capable of specifically hybridizing to rRNA of Campylobacter jejuni, C. coli and C. laridis and not to rRNA or rRNA genes of Pseudomonas aeuroginosa, E. coli or Salmonella typhimunium are described along with methods utilizing such probes for the detection of Campylobacter in clinical, food and other samples.

Detection of campylobacter with nucleic acid probes

Nucleic acid probes capable of hybridizing to rRNA sequences of Neisseria gonorrhoeae and not to rRNA sequences of non-Neisseria gonorrhoeae are described along with methods utilizing such probes for the detection of Neisseria gonorrhoeae in clinical and other samples.

Nucleic acid probes for the detection of Neisseria gonorrhoeae

Nucleic acid probes are described for detecting yeasts capable of causing Candida infection, specifically yeasts of the genera Candida, Torulopsis, and Yarrowia. The preferred probes are complementary to ribonucleic acid sequences unique to specific Candida species, or groups of such species, and as such can detect the rRNA, rDNA, or polymerase chain reaction amplification products of these genes. Methods for detecting the etiological agent of human Candida fungemia utilizing these probes are also provided.

Nucleic acid probes and methods for detecting pathogenic candida yeasts

Nucleic acid probes capable of hybridizing to rRNA of eubacteria and not to rRNA of non-eubacteria are described along with methods utilizing such probes for the detection of eubacteria in clinical and other samples. Preferred embodiments include probes capable of distinguishing between gram-positive and gram-negative bacteria.

Universal eubacteria nucleic acid probes and assay methods

Improved nucleic acid probes capable of specifically hybridizing to rRNA of Listeria and not to rRNA of non-Listeria are described along with methods utilizing such probes for the detection of Listeria in food and other samples.

Growing community of inventors

Milford, MA, United States of America

David J Lane