Riker Laboratories Inc.

Minnesota Mining and Manufacturing Company

3m Innovative Properties Company

Tarlochan S. Purewal

David J. Greenleaf

David J Greenleaf

Peter D Hodson

Philip A Jinks

Stephen J Howgill

Tarlochan S Purewal

Graham R Purkins

Gary D Mahon

Gustavo H Castro

Andrew M Bryant

Eric A Baum

Paul A Robertson

Lee A Kristensen

Sarah Jones

Heinz G Klein

Peter H Howarth

Matthew A Oakley

A dose counter for use with an inhaler comprising a container for medicament equipped with a reciprocal actuation means to dispense a dose of medicament therefrom, the dose counter comprising: a fixed ratchet member, a trigger member constructed and arranged to undergo reciprocal movement coordinated with the reciprocal movement between the actuation means and the container, said reciprocal movement comprising an outward stroke and a return stroke, a counter member constructed and arranged to undergo a predetermined counting movement each time a dose is dispensed, the counter member being biased towards the ratchet and trigger members and being capable of counting motion in a direction generally orthogonal to the direction of reciprocal movement of the trigger member, the counter member comprising: a first region for interaction with the trigger member which comprises at least one inclined surface which is engaged by the trigger member during its outward stroke causing the counter member to undergo counting motion, and a second region for interaction with the ratchet member which comprises at least one inclined surface which is engaged by the ratchet member during the return stroke of the trigger member causing the counter member to undergo further counting motion to complete said predetermined counting movement.

Dose counter for dispensers

The present invention relates to a novel design for a metering valve that provides improved consistency of formulation delivery. Generally, the metering valve includes (a) a valve stem that generally defines a longitudinal axis and includes a body portion having a metering surface, wherein the longitudinal axis and a plane tangential to at least a portion of the metering surface define an angle from about 2&#xb0; to about 90&#xb0;; and (b) a valve body having an internal chamber defined at least in part by the body wall and includes a metering portion configured to substantially conform to the metering surface of the valve stem.

Metering valve for a metered dose inhaler providing consistent delivery

Valve stems for use in an aerosol metering valve are described herein. The valve stems include structures designed to limit the likelihood and extent to which a gasket can intrude into an opening in the valve stem. The valve stems described herein also limit the likelihood and extent of damage to the gasket caused by repeated use of the metering valve.

Valve stem for use in a metering valve of a metered dose inhaler

A medicinal aerosol formulation including 0.01-5% medicament, at least 50% by weight 1,1,1,2-tetrafluoroethane (134 ), less than 5% surface active agent, and at least one compound having higher polarity than 1,1,1,2-tetrafluoroethane, and which is free of chlorofluorocarbons and propellants CHClF , CH F and CF CH .

CRC-free medicinal aerosol formulations of 1,1,1,2-tetrafluoroethane (134A) with polar adjuvant

A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.

Medicinal aerosol formulations

A self-propelling aerosol formulation which may be free from CFC's comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.

An inhalation device including an aerosol generator for dispensing droplets of liquid medicament comprising a housing defining a liquid receptacle having an opening, a nozzle arrangement comprising a plurality of orifices, vibrating means for vibrating the nozzle arrangement, and means for introducing the liquid medicament on the outer surface of the nozzle arrangement. Control means are also provided for controlling the vibrating means such that when the liquid medicament is introduced on the outer surface of the nozzle arrangement, the nozzle arrangement may be vibrated to cause the liquid to enter the liquid receptacle through the orifices and thereafter be expelled from the orifices through the outer surface of the nozzle arrangement in the form of atomised droplets.

Inhaler

A deagglomerator that defines a channel for passage of powder laden air, which channel changes its geometry in response to changing inhalation flow rate.

Growing community of inventors

Loughborough, United Kingdom

David J Greenleaf