Darwin Discovery Limited

Institute for Systems Biology

Ucb Pharma, S.a.

Keck Graduate Institute

Other

Battelle Memorial Institute

The Ohio State University

Ucb S.a.

Celltech R&d Limited

Centre De Recherche Public De La Sante

Ucb Manufacturing, Inc.

David J Galas

Jeffrey Van Ness

Brian Robert Kovacevich

John Thomas Mulligan

Mary E Brunkow

Bryan W Paeper

David Guenther Winkler

Kai Hua Wang

Shile Zhang

David J Winkler

Lori K Van Ness

Rudolph Emile Tanzi

Thomas D Bird

Richard Evan Gelinas

Gerard D Schellenberg

Clay Braden Marsh

Wilma Wasco

Melissa Garnet Piper

Ephrat Levy-Lahad

Etienne Moussay

Guy Berchem

Kai Wang

A novel class or family of TGF-&#x3b2; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.

Compositions and methods for increasing bone mineralization

Improved methods to quantitate RNA in biological or other analytical samples employ extended RNAs containing adaptors at the 5' end and polyA sequences coupled to a tag at the 3&#x2032; end. The invention method is particularly useful in quantitating microRNAs as primers can be used that need not complement the non-conserved 3&#x2032; ends of these molecules.

Methods to detect and quantify RNA

Described herein are pharmaceutical compositions comprising an anti-sclerostin antibody and an inhibitor of bone resorption.

New markers in the form of miRNA levels in plasma are provided for indicating the presence of CLL in a subject as well as suggesting routes of therapeutic treatment.

Diagnosis and treatment of chronic lymphocytic leukemia (CLL)

Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.

Methods, compositions, and devices utilizing MicroRNA to determine physiological conditions

Compositions and methods for protecting and administering small RNA to preserve stability are described. The small RNAs may either be in unmodified form or may be chemically modified to enhance stability further.

Compositions for protection and cellular delivery of interfering RNA

Compositions and methods for increasing bone density using antibodies directed to a novel class or family of TGF-&#x3b2; binding proteins are provided. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis.

Antibodies associated with alterations in bone density

Nucleic acids relating to human TGF-&#x3b2; binding proteins are disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.

Antibodies to a novel family of TGF-&#x3b2; binding proteins are disclosed, for use in methods of altering bone density and bone mineralization, which methods are applicable to the treatment of diseases including osteopenia and osteoporosis.

Methods for modulating bone mineralization

The present invention provides methods and kits for amplifying target nucleic acids (including whole genomes) using nicking agents. In certain aspects, the amplification does not require the use of any external oligonucleotide primers that are capable of annealing to a portion of the target nucleic acid. This invention is useful in many areas such as genetic disease diagnoses, forensic analyses and palcoarcheological studies.

Nucleic acid amplification using nicking agents

The present invention provides methods and compositions for nucleic acid methylation analysis using nicking agents.

Methylation analysis using nicking agents

Compositions and methods for increasing bone density using antibodies directed to a novel class or family of TGF-&bgr; binding proteins are provided. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis.

A novel class or family of TGF-&bgr; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.

Growing community of inventors

Mercer Island, WA, United States of America

David J Galas