Smithkline Corporation

Schering Corporation

Smithkline Beckman Corporation

David J Cooper

Jay Weinstein

Jay A Waitz

Joseph R Valenta

Mae Counelis

John R Hoover

Kenneth M Snader

Jerry Arnold Weisbach

Marcia C Shearer

Claude H Nash, Iii

Francis R Pfeiffer

George W Gebhardt

Francis E Wdzieczkowski

In the fermentation production of gentamicin C a plurality of additional antibiotic compounds are obtained. Four of these compounds, gentamicin A, gentamicin B, gentamicin B.sub.1 and gentamicin X exhibit significant anti-protozoal and anthelmintic activity while gentamicin B and B.sub.1 have significant antibacterial properties with markedly reduced side affects.

Amino glycoside antibiotics having antiprotozoal and anthelmintic

A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragile Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin complex and its major bioactive component, fragilomycin A, exhibit antibiotic activity.

Anthracycline antibiotics produced by streptosporangium fragile

A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragilis Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin complex and its major bioactive component, fragilomycin A, exhibit antibiotic activity.

Anthracycline antibiotics produced by Streptosporangium fragilis Shearer

In the fermentation production of gentamicin C a plurality of additional antibiotic compounds are obtained. Four of these compounds, gentamicin A, gentamicin B, gentamicin B.sub.1 and gentamicin X exhibit significant anti-protozoal and anthelmintic activity while gentamicin B and B.sub.1 have significant antibacterial properties with markedly reduced side effects.

Amino glycoside antibiotics having antiprotozoal activity

Amino glycoside antibiotics having antibacterial activity

A liquid fraction collector has a first series of containers and a second series of containers, each of the first and second series of containers being arranged in a plurality of groups with means to support each group at a different elevation. A conduit leads upwardly from each container in said first series with the upper ends of the conduits lying in a first row and a conduit leads upwardly from each container in said second series with the upper end of the conduits lying in a second row parallel to the first row. A carriage is mounted above said conduits. The carriage has means to discharge a liquid having an inverted V guide member with one trough over one row and the other trough over the other row and a discharge tube having its discharge end movable from a position over one trough of the guide member to a position over the other trough of the guide member. The carriage is advanced stepwise from one conduit to the next above the said rows from one end of rows to the other end and returned to said one end by moving means. The discharge tube discharges into the conduits of one row as the carriage advances and is moved to cause discharge into the conduits of the other row when the carriage returns by adjusting means.

Automatic fraction collector

Novel pseudodisaccharide compounds which are related to neamine are prepared. These compounds have a mercapto group or a derivative thereof at position 3 or 4 of the glucose moiety of neamine. The compounds have antibacterial activity and have utility as intermediates to pseudotrisaccharides.

Mercaptopseudotrisaccharides

Novel deoxy derivatives of neamine are prepared and disclosed as antibacterial agents.

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Downingtown, PA, United States of America

David J Cooper