Kulicke & Soffa Holdings, Inc.

Earlens Corporation

Raychem Limited

Alcon, Inc.

Caliper Life Sciences, Inc.

Apieron Biosystems Corp.

Caliper Technologies Corporation

Aerocrine Ab

Powervision, Inc.

Aperon Biosystems Corp.

David J Chazan

Jonathan P Fay

David James Anvar

Sunil Puria

Bryan Patrick Flaherty

Micha Rosen

Bhairavi Parikh

Jake L Olsen

Jan I Strandberg

Andrew Goodwin

Solomon I Beilin

James Stone

Sundar M Kamath

Kevin Nason

John Kaiser

Robert S Dubrow

Michael P Skinner

Robert E Nagle

Richard J McReynolds

James L Lykins

Michael J Katila

Ernest C W Lee

Luc J Bousse

Calvin Y H Chow

Colin B Kennedy

David D Liu

Michael A Spaid

Chi-Ming Chan

Khushroo Gandhi

Pradeep Barma

Carlton F Brooks

Ted T Chen

Richard F Otte

Gary R Weihe

Todd S Kaplan

David J Anvar

Derek Louch

Autumn Talbott

Johnathan Fay

Brian A Awabdy

Bhairavi R Parikh

David Anvar

Fluids incorporated into intraocular lenses and their methods of use. In some embodiments the fluids are silicone oils, and in some embodiments they are used in accommodating intraocular lenses.

Fluid for accommodating intraocular lenses

Embodiments of the present invention provide improved methods and apparatus suitable for use with hearing devices. A vapor deposition process can be used to make a retention structure having a shape profile corresponding to a tissue surface, such as a retention structure having a shape profile corresponding to one or more of an eardrum, the eardrum annulus, or a skin of the ear canal. The retention structure can be resilient and may comprise an anatomically accurate shape profile corresponding to a portion of the ear, such that the resilient retention structure provides mechanical stability for an output transducer assembly placed in the ear for an extended time. The output transducer may couple to the eardrum with direct mechanical coupling or acoustic coupling when retained in the ear canal with the retention structure.

Anatomically customized ear canal hearing apparatus

A high-sensitivity analyzer for nitric oxide in exhaled breath at levels of 200 ppb or less with a sensor containing cytochrome C is rendered capable of multiple uses without the need for installing a new sensor for each use. This capability is achieved by regenerating the analyzer after each use by purging the sensor and surrounding regions with NO-free air in a controlled manner, preferably in pulses separated by equilibration periods.

Analyzer for nitric oxide in exhaled breath with multiple-use sensor

The present invention is a disposable sensor for use with a device that quantifies analytes in a gaseous sample. It comprises (i) a sensing element, (ii) a means for interfacing the disposable sensor with a gas analysis device, and (iii) a housing. When used with a device that can quantify the concentration of an analyte in a gas sample, the present invention facilitates the use of exhaled breath analysis as a clinical tool.

Disposable sensor for use in measuring an analyte in gaseous sample

Highly sensitive devices for detecting nitric oxide and/or other gaseous analytes in gaseous samples are improved by the incorporation of a carbon monoxide scavenger in the interior of the device or in the device packaging. The release of carbon monoxide within the housing of the device by the plastic used in the construction of the housing or by anything within the device that releases carbon monoxide causes a loss in sensitivity due to competition between the carbon monoxide and the nitric oxide for the binding sites on the device sensor. The scavenger corrects this by either catalyzing the oxidation of carbon monoxide to the less competitive carbon dioxide or immobilizing the carbon monoxide by affinity-type or covalent binding. Analogous effects are achieved for analytes other than nitric oxide but that likewise encounter interference from carbon monoxide in binding to sensors.

Reduction of carbon monoxide interference in gaseous analyte detectors

Disposable sensor for use in measuring an analyte in a gaseous sample

Methods and devices that include the use of venting elements for enhancing bonded substrate yields and regulating temperature. Venting elements are generally fabricated proximal to functionalized regions in substrate surfaces to prevent bond voids that form during bonding processes from affecting the functionalized regions. Venting elements generally include venting channels or networks of channels and/or venting cavities.

Methods and devices for enhancing bonded substrate yields and regulating temperature

The degradation over time that is commonly seen with analyte-binding proteins when used as sensors for trace amounts of an analyte in a gaseous mixture is reduced by maintaining the sensor in a low-oxygen or oxygen-free environment.

Trace gas sensor with reduced degradation

Growing community of inventors

Palo Alto, CA, United States of America

David J Chazan