Dartmouth College

Other

David J Bzik

Barbara A Fox

Joseph W Inselburg

Jose R Conejo-Garcia

Steven N Fiering

Tomohiko Sugiyama

Jason Baird

Kiah L Sanders

Toshihiro Horii

Attenuatedmutants and methods using the same as vaccines in the prevention or treatment pancreatic cancer are provided.

Method for treating pancreatic cancer withvaccine

The present invention provides attenuatedmutants for use as vaccines in the prevention or treatment of cancer.

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Uracil auxotroph mutants of apicomplexans are provided which lack a functional carbamoyl phosphate synthase II (CPSII) enzyme. Also provided areautoxtroph mutants which express exogenous antigens, and methods of protecting an animal against aand non-disease.

Attenuated uracil auxotroph of an apicomplexan and use thereof

The present invention provides attenuatedknockout mutants of the de novo pyrimidine synthesis pathway and use of the same in vaccines and methods of providing an immune response and protecting a subject against infection byand a non-disease.

The present invention relates to a mutantwhich exhibits enhanced homologous recombination. The mutant of the present invention is a knockout in the KU80-dependent nonhomologous end-joining pathway which finds application in generatinggene knockouts and gene replacements for use in vaccine and drug development.

Gene encoding protein antigens of Plasmodium falciparum and uses therefor

A Plasmodium falciparum gene encoding immunogenic SERA protein has been isolated by a) systematically screening a lambda gt11 recombinant DNA expression library with a murine monoclonal antibody directed against protein antigens of this pathogen, and b) systematically screening a lambda gt11 genomic cDNA and oligonucleotide probes directed against this pathogen. A 111 kDa protein has been shown to have immunogenic activity against parasite inhibitory antibodies. The gene encoding this protein, including the signal sequence and regulatory sequence in the adjacent 5' flanking sequence has been isolated and sequenced. Isolation and characterization of genes encoding major protein antigens of P. falciparum make it possible to develop reagents useful in the diagnosis, prevention and treatment of malaria. In addition, the signal sequences or regulatory sequences of this gene can be used to stimulate the production of other useful genetic products.

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Grantham, NH, United States of America

David J Bzik