Poly-med, Inc.

Strategic Medical Solutions, Llc.

David Ingram

Shalaby Wahba Shalaby

Michael Aaron Vaughn

Georgios T Hilas

Sheila Nagatomi

Seth Dylan McCullen

Joel Thomas Corbett

James M Lindsey

Scott Taylor

William Thomas Stephens, Jr

Robert Laudadio

David E Linden

Melissa Vinci-Rainis

Stabilized monomer and polymer adhesive compositions useful in the formulation of biomedical adhesives and sealants for application to living tissue are provided.

Adhesive composition for wound closure

Bioactive hydroforming luminal liner compositions are formed of an absorbable crystalline amphiphilic polyether-ester-urethane dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.

Absorbable crystalline polyether-ester-urethane-based bioactive luminal liner compositions

Biomedical and tissue engineering devices, such as surgical sutures and microporous scaffolds, respectively, which undergo swelling and increase in dimensions when placed in aqueous environments such as living tissues, are produced by the melt-spinning or electrostatic spinning into strong monofilament and multifilament yarns or microfibrous fabrics, respectively. Such devices are formed from especially high molecular weight crystalline polyether-esters having a minimum inherent viscosity of 0.8 dL/g and heat of fusion of at least 5 J/g, wherein the polyether-esters are made by grafting to a polyester component a polyether glycol component having a minimum molecular weight of about 11 kDa with at least one cyclic monomer.

Swellable fiber and microfiber forming polyether-esters and applications thereof

Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.

Hydroswellable, segmented, aliphatic polyurethanes and polyurethane ureas

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Central, SC, United States of America

David Ingram