Abbvie Inc.

H. Lundbeck A/s

David Ihle

Michael M Friedman

Kelly Mullen

Eric C Breinlinger

Noel S Wilson

Justin D Dietrich

Augustine Osuma

Andrew Burchat

Anil Vasudevan

Thomas D Gordon

Michael Morytko

Kevin Patrick Cusack

David Andrew Kinsman

Gloria Y Lo Schiavo

Jun Yuan

Michael Z Hoemann

Maria A Argiriadi

Kevin J Hodgetts

Qin Guo

Lei Wang

Martin E Hayes

Gagandeep K Somal

Bin Li

Wouter Iwema Bakker

Gloria Y LoSchiavo

The disclosure provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the disclosure are useful for treating immunological and oncological conditions.

Indazolones as modulators of TNF signaling

The disclosure provides indazolone compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the disclosure may be useful for treating immunological and oncological conditions.

Indazolones as modulators of tnf signaling

The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Heterocyclic nuclear hormone receptor modulators

Heteroaryl amide analogues are provided, of Formula (I), wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies. 

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Worcester, MA, United States of America

David Ihle