Photopharmica Limited

David Ian Vernon

John Griffiths

Stanley Beames Brown

Kirste Joanne Mellish

Cassandra Claire O'Grady

Richard George Tunstall

David John Howard Roberts

The present invention relates to a composition which includes a moiety of formula 

Biologically active methylene blue derivatives

The present invention relates to a method of photodynamic therapy and to a method of inducing a photocytoxic effect which comprises applying to an area to be treated an effective amount of a compound of formula in which R, R, Rand Reach independently is an optionally -substituted linear, branched or cyclic hydrocarbon group, or Rand Rtogether with the N atom to which they are attached form an optionally substituted 5-, 6- or 7- membered ring or Rand Rtogether with the N atom to which they are attached form an optionally substituted 5-, 6- or 7- membered ring;

A phenothiazinium compound of Formula (I) wherein: 

The present invention relates to a pharmaceutical composition which contains a compound of formula in which R, R, Rand Rare each n-butyl, where Xis a counteranion and P is 1, 2 or 3, together with a pharmaceutically acceptable carrier, excipient or adjuvant.

A phenothiazinium compound of Formula (I): wherein: in which R' and R&#x2033; each independently is a linear, branched or cyclic hydrocarbon group, or R&#x2032; and R&#x2033; together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7-membered ring;

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Chapel Allerton, United Kingdom

David Ian Vernon