Paloma Pharmaceuticals, Inc.

Oxigene, Inc.

Baylor University

Applied Research Systems Ars Holding N.v.

David I Sherris

Ronald W Pero

Mark Hilary Cunningham

Miklos Feher

Fupeng Ma

Kevin G Pinney

Sean D McKenna

Mark Tepper

Zhi Chen

Vani P Mocharla

Robert Dunn-Dufault

Peter Redden

Nabil El Tayar

Sanjivanjit Kaur Bhal

Manjinder Gill

Jonathan Schmidt

Described herein are compositions and methods for preventing and/or treating diseases involving aberrant angiogenesis employing one or more benzo[c]chromen-6-one derivatives.

Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis

Methods and compositions for reducing radiation damage in a subject with analog or derivative of benzo[c]chromen-6-one.

Radiation countermeasure agents

Treatment of warm-blooded animals having a tumor or non-malignant hypervascularation, by administering a sufficient amount of a cytotoxic agent formulated into a phosphate prodrug form having substrate specificity for microvessel phosphatases, so that microvessels are destroyed preferentially over other normal tissues, because the less cytotoxic prodrug form is converted to the highly cytotoxic dephosphorylated form.

Compositions and methods for use in targeting vascular destruction

The in vivo effect of Type I interferon (IFN) can be prolonged by administering the interferon in the form of a complex with an IFN binding chain of the human interferon &agr;/&bgr; receptor (IFNAR). Such a complex also improves the stability of the IFN and enhances the potency of the IFN. The complex may be a non-covalent complex or one in which the IFN and the IFNAR are bound by a covalent bond or a peptide. When bound by a peptide bond in the form of a fusion protein, the IFN may be separated from the IFNAR by means of a peptide linker. Such a fusion protein may be produced by recombinant DNA technology. Storing IFN in the form of such a complex improves the storage life of the IFN and permits storage under milder conditions than would otherwise be possible.

IFNAR2/IFN complex

Growing community of inventors

Jamaica Plain, MA, United States of America

David I Sherris