New York University

David I Schuster

Randall B Murphy

Bing Cai

Compounds, compositions and methods involving purified, isolated and/or synthetic G-protein coupled receptor (GPR) polypeptides that comprise fragments, derivatives and/or consensus peptides of transmembrane domains of G-coupled receptor proteins, wherein the GPR polypeptide has biological activity selected from binding of a GPR ligand to a GPR or modulating the binding of a GPR ligand to a GPR.

Polypeptide derived from a popamine receptor, and compositions and

Stereoisomeric substituted and/or unsubstituted octahydronaphthoquinolizines (OHNQs), and derivatives and analogs thereof are provided, including pharmaceutical and diagnostic compositions, as well as methods of making and using these compounds according to the following formula I: ##STR1##

Growing community of inventors

Wilton, CT, United States of America

David I Schuster