Insulet Corporation

Apple Inc.

Ivenix, Inc.

David I Nazzaro

Ian T McLaughlin

Maureen McCaffrey

Tyler S Bushnell

Daniel Allis

Trevor J Ness

Simon Kozin

Fletcher R Rothkopf

Steven P Cardinali

Jason B O'Connor

Makiko K Brzezinski

Jonathan P Ive

Duncan Robert Kerr

Bartley K Andre

Richard P Howarth

Eugene Antony Whang

Peter N Russell-Clarke

Christopher J Stringer

Daniele De Iuliis

Daniel J Coster

Jody R Akana

Matthew Dean Rohrbach

Jeremy D Bataillou

Julian Hoenig

Shota Aoyagi

Benjamin Andrew Shaffer

Anthony Michael Ashcroft

Mikael M Silvanto

Marc A Newson

Stephen Paul Zadesky

Eric Steven Jol

Phillip Michael Hobson

Naoto Matsuyuki

Brad G Boozer

Rico L Zorkendorfer

Martha Evans Hankey

Benjamin J Kallman

Jeff Barnes

Jackie Mac

Michael Benjamin Wittenberg

Colin M Ely

Anna-Katrina Shedletsky

Christopher Matthew Werner

Samuel Bruce Weiss

Jason C Sauers

David M Pelletier

John D'Arco

Steven James Martisauskas

John R Bussiere

Alexander Patt Broerman

Melinda Freson

Alexander Doudoumopoulos

Bhavin Patel

Robert F Rioux

Serhan O Isikman

Joon Bok Lee

Andrzej T Baranski

Chin San Han

Ashutosh Zade

Thomas Metzmaker

Marcelo M Lamego

Joseph C Poole

Ibuki Kamei

Kevin M Kenney

Wolf Oetting

Javier Mendez

Nicholas Conte

Timothy Henning

M Evans Hankey

Erik G De Jong

Rico Zörkendörfer

Jesse E Ambrosina

Adam Thomas Clavelle

Yibin Zheng

Ueyn L Block

Benjamin G Powers

Tobias J Harrison-Noonan

Jason O'connor

Scott M Nathanson

Kenneth Phillips

Bin Yi

Alexander J Segit

Jairam Manjunathaiah

Bryan Dillon

Raul Molina

Robert D Schaefer

Bryan Choate

Eric Benjamin

Ian Mclaughlin

David Clare

Dezheng Qu

Steven Barletta

Raymond Dobry

John LeFavour

Inori Iwata

Raul A Molina

Maureen Mccaffrey

Lawrence S Ring

Michael Philip Graffeo

Nicholas Jansky

Systems and methods for monitoring an operational state and/or a fill status of a drug container of a drug delivery device are provided. The drug container can hold a liquid drug. A plunger can be positioned within the drug container. A drive system can advance the plunger to expel the liquid drug from the container. A monitoring system can detect a movement and/or a position of the plunger and/or any component coupled to the plunger. The detection can enable determination of an amount of liquid drug that has been expelled and/or an amount of liquid drug remaining in the drug container. Dosing rates, flow rates, and dosage completion can also be determined.

Drug delivery device with indicator

Disclosed are examples of devices, systems and techniques for delivering a liquid drug. An example delivery pump device may include a chamber body defining a pump chamber, an inlet valve to receive a liquid drug and a hard stop. A plunger configured with a plunger channel. A sliding fluidic member including a needle coupling, a flow orifice, a face seal and an anchor portion that may be movable within the pump chamber. A pump mechanism may be coupled to the anchor portion and operable to pull the anchor portion and the plunger toward the hard stop. Techniques may include determining a time to output a liquid drug from the delivery pump device; generating a control signal to actuate the delivery pump device; applying a control signal to the pump mechanism; determining that a control signal is to be removed from the pump mechanism; and delivering the liquid drug.

Single actuated precision dose intermediate pumping chamber

A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.

On-body interlock for drug delivery device

Disclosed are examples of a device, a system, methods and computer-readable medium products operable to implement functionality to determine and respond to a purpose of a meal. An algorithm or application may receive data that may include data related to a meal purpose from data sources and determine whether any of the data received from the plurality of data sources was received from a direct data source or an indirect data source. The data may be evaluated to determine a purpose of the meal. Based on the results of the evaluation, instructions may be generated to provide an appropriate response based on the determined purpose of the meal. The generated instructions to provide the appropriate response based on the determined purpose of the meal may be output.

Early meal detection and calorie intake detection

Embodiments of the present disclosure relate to approaches for more efficiently measuring glucose levels using a wearable drug delivery device. In some embodiments, the wearable drug delivery device may include a needle deployment component including a cannula and an optical conduit deployable into a user, the cannula operable to deliver a liquid drug to the user. The wearable drug delivery device may further include a glucose monitor including an optical sensor, the optical sensor operable to measure a light output received via the optical conduit.

Drug delivery device with integrated optical-based glucose monitor

The exemplary embodiments may provide a secure framework for devices in a drug delivery system to wirelessly communicate. The secure framework may use encrypted keys to carry credentials and to specify the rights of the devices presenting the credentials. The devices in the drug delivery system present the keys at the time that they wish to wirelessly communicate with other devices in the drug delivery system. The devices receiving such keys, decrypt the keys and verify if the credentials are valid. If the credentials are valid, a wireless communication session between devices may be established.

Secure wireless communications between a glucose monitor and other devices

Housing for an electronic device

Systems and methods for performing damping analyses on a device are disclosed. The damping analyses may be used by a device in numerous ways. For example, in some embodiments, damping analyses are used to determine whether a device is being worn or held by a user. In some embodiments, damping analyses are used to determine which user of multiple users is wearing a device. In some embodiments, damping analyses are used to determine the body composition of a user who is holding or wearing the device. In some embodiments, damping analyses are used to determine how much force a user is applying to a device via a touch input. In some embodiments, damping analyses are used to determine whether and to what extent a sensor is in contact with a body of a user.

Band adjustment for electronic devices

Disclosed are examples for a system for drug delivery and components thereof. The system may include an on-body pump device and a secondary unit. The on-body pump device may include a reservoir and a fluid pathway. The reservoir may be configured to hold a liquid drug. The secondary unit may be removably coupled to the on-body pump device. The secondary unit may be configured to receive a prefilled cartridge containing a liquid drug, expel the liquid drug from the prefilled cartridge, and deliver the liquid drug to the reservoir of the on-body pump device via the fluid pathway. Examples of variations to the secondary unit are also disclosed.

Drug delivery insertion apparatuses and system

Disclosed are a device, system, methods and computer-readable medium products that provide an updated insulin-to-carbohydrate ratio and an updated total daily insulin. The described processes may be used for periodic updating of the insulin-to-carbohydrate ratio and the total daily insulin. The insulin-to-carbohydrate ratio and/or the total may be used in the calculation of new doses of insulin that a drug delivery device may be commanded to deliver to a user.

Techniques and devices providing adaptivity and personalization in diabetes treatment

A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can include a spring coupled to a plurality of force transfer elements. The force transfer elements can have a variety of shapes and configurations.

Drug delivery devices, systems, and methods with force transfer elements

Systems and methods for automatically delivering medication to a user. A sensor coupled to a user can collect information regarding the user. A controller can use the collected information to determine an amount of medication to provide the user. The controller can instruct a drug delivery device to dispense the medication to the user. The drug delivery device can be a wearable insulin pump that is directly coupled to the user. The controller can be part of or implemented in a cellphone. A user can be required to provide a confirmation input to allow a determined amount of insulin to be provided to the user based on detected glucose levels of the user. The sensor, controller, and drug delivery device can communicate wirelessly.

Wearable automated medication delivery system

Drive systems for a drug delivery device are provided. The drive systems can be positioned within a container that stores a liquid drug to be delivered to a user. The drive systems can be coupled to a plunger positioned within the container. The drive systems can be incrementally advanced to drive the plunger further into the container, thereby expelling a portion of the stored liquid drug from the container for delivery to the user. The container can be any type of container including a pre-filled, standardized drug cartridge. The drive systems and container can be components of a wearable drug delivery device.

Drug cartridge with drive system

Disclosed are examples of reservoir and reservoir systems usable with a wearable drug delivery device. An example reservoir may include a flexible component coupled to a shell component. The shell component may include drainage channels to facilitate extraction of the liquid drug from the reservoir. A reservoir system example may include an exoskeleton configured around a flexible reservoir to guide the expansion and collapse of the flexible reservoir. Alternatively, one or more rigid panels may be coupled to corresponding flat surfaces of the flexible reservoir to guide the expansion and collapse of the flexible reservoir. A further reservoir example may include a flexible thin film reservoir having peel-able restraints configured to seal off corresponding sections of the reservoir, sequentially break, enabling the liquid drug to sequentially fill corresponding sections in a controlled and predicable manner. A wearable drug delivery device example suitable for utilizing the described examples is provided.

Semi-rigid and flexible elements for wearable drug delivery device reservoir

Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.

Cartridge hold-up volume reduction

Growing community of inventors

Saratoga, CA, United States of America

David I Nazzaro