The Wellboss Company, LLC

Cidara Therapeutics, Inc.

Napp Pharmaceutical Group Limited

David Hughes

Evan Lloyd Davies

Luis Miguel Avila

Balasingam Radhakrishnan

Gabriel Antoniu Slup

Yi Xia

Martin Patrick Hughes

Robert Michael Hughes

Navdeep Balkrishna Malkar

Ashley Holbrooks

Anuradha Vaidya

Kenneth Bartizal

Paul Daruwala

Xiao Wu

Christopher Yantsides

Yannick Borguet

Rachelle D Fitzgerald

Irtiza Ali

Ashton E Diaz

Steven McIntyre

Duke VanLue

Yanan Hou

Duke Vanlue

Liguo Li

David Takashi Takamoto

Naoki Sadakuni

The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides.

Synthesis of echinocandin antifungal agent

The disclosure features non-irritating pharmaceutical compositions containing CD101 in pharmaceutical acceptable salt (e.g., CD101 acetate) or neutral form. The pharmaceutical compositions can be intravenously administered to a subject to treat fungal infections (e.g., candidiasis) in the subject.

Compositions and methods for the treatment of fungal infections

A downhole tool having a mandrel, and a bottom slip disposed around the mandrel. The bottom slip includes a circular body having a one-piece configuration characterized by a plurality of slip segments by at least partial material connectivity therearound. The bottom slip is made of a filament wound composite material, which means the bottom slip has a plurality of layers joined by respective interface layers. An outer slip surface of at least one of the plurality of slip segments is defined in cross-section by a plane P that intersects a longitudinal axis of the downhole tool at an angle awhen the bottom slip is in an unset position.

Downhole tool with bottom composite slip

A downhole tool having a mandrel, and a bottom slip disposed around the mandrel. The bottom slip includes a circular body having a one-piece configuration characterized by a plurality of slip segments by at least partial material connectivity therearound. The bottom slip is made of a filament wound composite material, which means the bottom slip has a plurality of layers joined by respective interface layers. An outer slip surface of at least one of the plurality of slip segments is defined in cross-section by a plane P that intersects a longitudinal axis of the downhole tool at an angle ain a range of 10 degrees to 20 degrees when the bottom slip is in an unset position.

A downhole tool having a mandrel, a first slip, a second slip, a lower sleeve, and a tethered ball assembly. The mandrel includes a proximate end; a distal end; a bore having a ball seat associated therewith; and an outer surface. The first slip is disposed around the mandrel. The second slip is disposed around the mandrel. The lower sleeve is proximate to the first slip, and engaged with the outer surface at the distal end. The tethered ball assembly includes a ball; a drag; and at least one tether coupled between the ball and the drag.

Downhole tool with tethered ball

A downhole tool suitable for use in a wellbore, the tool comprising a hybrid sleeve in the form of a mandrel sleeve; and a sleeve insert disposed within the mandrel sleeve. The tool further includes a first slip disposed about the mandrel sleeve; and a second slip disposed about the mandrel sleeve and proximate to a conical surface. There is a lower sleeve proximate to the second slip. At least a portion of the sleeve insert is radially laterally proximate to a sealing element disposed around the mandrel.

Downhole tool and methods of use

One-piece slip

Growing community of inventors

Houston, TX, United States of America

David Hughes