Neumora Therapeutics, Inc.

Blackthorn Therapeutics, Inc.

Ares Trading S.a.

Mmv Medicines for Malaria Venture

David Hardick

Robert M Jones

Chris Knight

Mariangela Urbano

Gary Brandt

Jason Tierney

Chris Lock

Anna Quattropani

Mark Stewart Chambers

Vincent Pomel

Mark Stuart Chambers

Michael John Witty

Ben Whittaker

Dale Mitchell

Chris Steele

Dirk Beher

Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof: wherein Q, Q, Q, R, R, Rand X are as defined herein.

Vasopressin receptor antagonists and products and methods related thereto

Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof: wherein A, B, G, R, R, R, Rand X are as defined herein.

The present invention provides fused bicyclic triazole derivatives of Formula (I) useful as gamma secretase modulators (GSM), for the treatment of Alzheimer's disease and related diseases. 

Fused triazole derivatives as gamma secretase modulators

The present invention is related to a use of aminopyridine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyridine derivatives useful for the preparation of a pharmaceutical foimulation for the inhibition of malaria parasite proliferation.

Anti-malarial agents

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Saffron Walden, United Kingdom

David Hardick